Prognosis of Oligodendroglioma Patients Stratified by Age: A SEER Population-Based Analysis
文献类型：期刊论文
| 作者 | Jin, Kai; Zhang, Shu-Yuan; Li, Li-Wen; Zou, Yang-Fan; Wu, Bin ; Xia, Liang; Sun, Cai-Xing
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| 刊名 | INTERNATIONAL JOURNAL OF GENERAL MEDICINE
 |
| 出版日期 | 2021 |
| 卷号 | 14 |
| 关键词 | oligodendroglioma SEER age prognosis all-cause mortality tumor-specific mortality |
| DOI | 10.2147/IJGM.S337227 |
| 通讯作者 | Sun, Cai-Xing(8744016937@163.com) |
| 英文摘要 | Purpose: Glioma may affect patients of any age. So far, only a limited number of big data studies have been conducted concerning oligodendroglioma (OG) in diverse age groups. This study evaluated the risk factors for OG in different age groups using the Surveillance, Epidemiology, and End Results (SEER) database built by the National Cancer Institute, which is part of the National Institutes of Health. Patients and Methods: A total of 5437 cases within the SEER database were included. These patients were divided into seven age groups. The Kaplan-Meier method was employed for survival analysis. The independent risk factors for the survival of OG patients were identified using the Cox regression model. A nomogram was drawn with R software based on the independent risk factors. The X-tile software was adopted to find the optimal age group at diagnosis. Results: The all-cause mortality and the tumor-specific mortality increased with age. The univariate analysis showed that the patients' age, gender, primary lesion location, side affected by the primary lesion (left or right), surgery for the primary lesion, and tumor size were correlated with survival (P<0.05). Multivariate Cox regression analysis showed that age was an independent risk factor for the survival of OG patients (P<0.05). The optimal cutoff value of age in terms of overall survival (OS) and cause-specific survival (CSS) were identified as 48 and 61 years and 48 and 59 years, respectively. Conclusion: The older the age, the worse the survival would be. That's, the mortality increased with age. In the clinic, healthcare professionals should be fully aware of the variability in the prognosis of OG patients in different age groups. Therefore, individualized treatments are recommended to OG patients in different age groups to optimize the prognosis. |
| WOS关键词 | PEDIATRIC OLIGODENDROGLIOMA ; GRADE GLIOMA ; EPIDEMIOLOGY ; SURVEILLANCE ; OUTCOMES ; THERAPY ; TRENDS ; TUMORS |
| 资助项目 | Youth Fund of the National Natural Science Foundation[81502147] ; Zhejiang Province Natural Science Foundation[LY21H160007] ; Zhejiang Province Natural Science Foundation[LQ21H160006] ; Youth Scientific Research Program of Zhejiang Cancer Hospital[QN201902] |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| WOS记录号 | WOS:000730887300004 |
| 资助机构 | Youth Fund of the National Natural Science Foundation ; Zhejiang Province Natural Science Foundation ; Youth Scientific Research Program of Zhejiang Cancer Hospital |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/126934]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Sun, Cai-Xing |
| 作者单位 | Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Dept Neurosurg,Zhejiang Canc Hosp,Canc Hosp, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Kai,Zhang, Shu-Yuan,Li, Li-Wen,et al. Prognosis of Oligodendroglioma Patients Stratified by Age: A SEER Population-Based Analysis[J]. INTERNATIONAL JOURNAL OF GENERAL MEDICINE,2021,14. |
| APA | Jin, Kai.,Zhang, Shu-Yuan.,Li, Li-Wen.,Zou, Yang-Fan.,Wu, Bin.,...&Sun, Cai-Xing.(2021).Prognosis of Oligodendroglioma Patients Stratified by Age: A SEER Population-Based Analysis.INTERNATIONAL JOURNAL OF GENERAL MEDICINE,14. |
| MLA | Jin, Kai,et al."Prognosis of Oligodendroglioma Patients Stratified by Age: A SEER Population-Based Analysis".INTERNATIONAL JOURNAL OF GENERAL MEDICINE 14(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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