Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
文献类型：期刊论文
| 作者 | Li, Qinglin3; Xia, Liang2; Sun, Caixing2; Zhang, Huangjie1; Zheng, Mengying5; Zhang, Hongyan1; Lu, Hongyang4; Wang, Zeng1 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2021-11-30 |
| 卷号 | 11 |
| 关键词 | natural product borneol malignant glioma autophagy HIF-1 alpha |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2021.749987 |
| 通讯作者 | Zhang, Hongyan() ; Lu, Hongyang() ; Wang, Zeng() |
| 英文摘要 | Glioma is the common primary craniocerebral malignancy with unfavorable prognosis. It is currently treated by surgical resection supplemented by radiotherapy, although the resistance of glioma cells to radiation limits the therapeutic outcomes. The aim of the present study was to determine the potential radiosensitizing effects of borneol and the underlying mechanisms. We found that borneol administration along with radiotherapy significantly inhibited the growth of primary glioma cells in vitro and in vivo. Furthermore, borneol markedly increased the number of autophagosomes in the glioma cells, which coincided with increased expression of beclin-1 and LC3. And the combination of borneol and radiation exposure significantly decreased the expression levels of HIF-1 alpha, mTORC1 and eIF4E. In addition, silencing mTORC1 and eIF4E upregulated Beclin-1 and LC3 and decreased the expression of HIF-1 alpha, thereby inhibiting tumor cell proliferation. Our findings suggest that borneol sensitizes glioma cells to radiation by inducing autophagy via inhibition of the mTORC1/eIF4E/HIF-1 alpha regulatory axis. |
| WOS关键词 | EXPRESSION ; BECLIN-1 ; CELLS |
| 资助项目 | 1022 Talent Training Program of Zhejiang Cancer Hospital ; National Science of Foundation of China[81502147] ; Zhejiang Provincial National Science Foundation of China[LY20H290003] ; Zhejiang Provincial National Science Foundation of China[LGF18H280003] ; Zhejiang Provincial National Science Foundation of China[YY18H300008] ; Zhejiang Provincial National Science Foundation of China[LYQ20H280001] ; Zhejiang Medical and Health Science and Technology Project[2020KY477] ; Zhejiang Medical and Health Science and Technology Project[2020364926] ; Zhejiang Medical and Health Science and Technology Project[2019RC127] ; Zhejiang Medical and Health Science and Technology Project[2016ZQ009] ; Zhejiang Medical and Health Science and Technology Project[2020ZQ005] ; Zhejiang Medical and Health Science and Technology Project[2019ZD024] ; Chinese medicine science and technology plan of Zhejiang Province[2022ZB052] ; Chinese medicine science and technology plan of Zhejiang Province[2018KY291] ; Chinese medicine science and technology plan of Zhejiang Province[2021ZB036] ; Chinese medicine science and technology plan of Zhejiang Province[2016KYB038] ; [2018KY291,2016KYB038] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000733887700001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | 1022 Talent Training Program of Zhejiang Cancer Hospital ; National Science of Foundation of China ; Zhejiang Provincial National Science Foundation of China ; Zhejiang Medical and Health Science and Technology Project ; Chinese medicine science and technology plan of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/126966]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Hongyan; Lu, Hongyang; Wang, Zeng |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp,Zhejiang Canc Hosp,Dept Pharm, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp,Zhejiang Canc Hosp,Dept Neurotumor Surg, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Basic Med & Canc IBMC, Dept Sci Res,Canc Hosp,Zhejiang Canc Hosp, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Basic Med & Canc IBMC, Dept Thorac Oncol,Canc Hosp,Zhejiang Canc Hosp, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Basic Med & Canc IBMC, Dept Med Sch,Canc Hosp,Zhejiang Canc Hosp, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qinglin,Xia, Liang,Sun, Caixing,et al. Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma[J]. FRONTIERS IN ONCOLOGY,2021,11. |
| APA | Li, Qinglin.,Xia, Liang.,Sun, Caixing.,Zhang, Huangjie.,Zheng, Mengying.,...&Wang, Zeng.(2021).Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma.FRONTIERS IN ONCOLOGY,11. |
| MLA | Li, Qinglin,et al."Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma".FRONTIERS IN ONCOLOGY 11(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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