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Manipulation of Multiple Cell-Cell Interactions by Tunable DNA Scaffold Networks

文献类型：期刊论文

作者Guo, Zhenzhen1; Zhang, Lili1; Yang, Qiuxia1; Peng, Ruizi1,3; Yuan, Xi1; Xu, Liujun1; Wang, Zhimin1; Chen, Fengming1; Huang, Huidong1; Liu, Qiaoling1
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2021-12-23
ISSN号1433-7851
关键词Cell Encapsulation Cell Manipulation Cell-Cell Interactions DNA Nanotechnology DNA Scaffold Network
DOI10.1002/anie.202111151
通讯作者Liu, Qiaoling(qlliu@iccas.ac.cn) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要Manipulation of cell-cell interactions via cell surface engineering has potential biomedical applications in tissue engineering and cell therapy. However, manipulation of the comprehensive and multiple intercellular interactions remains a challenge and missing elements. Herein, utilizing a DNA triangular prism (TP) and a branched polymer (BP) as functional modules, we fabricate tunable DNA scaffold networks on the cell surface. The responsiveness of cell-cell recognition, aggregation and dissociation could be modulated by aptamer-functionalized DNA scaffold networks with high accuracy and specificity. By regulating the DNA scaffold networks coated on the cell surface, controlled intercellular molecular transportation is achieved. Our tunable network provides a simple and extendible strategy which addresses a current need in cell surface engineering to precisely manipulate cell-cell interactions and shows promise as a general tool for controllable cell behavior.
WOS关键词TUNNELING NANOTUBES ; T-CELLS ; SURFACE ; APTAMER ; RELEASE
资助项目NSFC[22022701] ; NSFC[21991084] ; National Key Research and Development Program of China[2019YFA0905800] ; Hunan Provincial Research and Development Plan in Key Areas[2019SK2201]
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000733416700001
资助机构NSFC ; National Key Research and Development Program of China ; Hunan Provincial Research and Development Plan in Key Areas
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/126970]  
专题中国科学院合肥物质科学研究院
通讯作者Liu, Qiaoling; Tan, Weihong
作者单位1.Hunan Univ, Coll Biol, Aptamer Engn Ctr Hunan Prov, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Hunan, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med IMM, Shanghai 200240, Peoples R China
3.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Zhenzhen,Zhang, Lili,Yang, Qiuxia,et al. Manipulation of Multiple Cell-Cell Interactions by Tunable DNA Scaffold Networks[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021.
APA Guo, Zhenzhen.,Zhang, Lili.,Yang, Qiuxia.,Peng, Ruizi.,Yuan, Xi.,...&Tan, Weihong.(2021).Manipulation of Multiple Cell-Cell Interactions by Tunable DNA Scaffold Networks.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA Guo, Zhenzhen,et al."Manipulation of Multiple Cell-Cell Interactions by Tunable DNA Scaffold Networks".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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