SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis
文献类型：期刊论文
| 作者 | Niu, De; Lin, Xiao-Li; Kong, Xiangxiong; Qu, Gao-Ping; Cai, Bin; Lee, Jiyoung1; Jin, Jing Bo |
| 刊名 | MOLECULAR PLANT
 |
| 出版日期 | 2019 |
| 卷号 | 12期号:2页码:215-228 |
| ISSN号 | 1674-2052 |
| 关键词 | immune response SIZ1 SUMO E3 ligase SUMO modification TOPLESS |
| DOI | 10.1016/j.molp.2018.12.002 |
| 文献子类 | Article |
| 英文摘要 | Plant immune responses are tightly regulated to ensure their appropriate deployment. Overexpression of TOPLESS-RELATED 1 (TPR1), a SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 (SNC1)-interacting protein, results in autoimmunity that reduces plant growth and development. However, how TPR1 activity is regulated remains unknown. Loss of function of SIZ1, a (SUMO) E3 ligase, induces an autoimmune response, partially due to elevated SNC1 levels. Here we show that SNC1 expression is upregulated in Arabidopsis thaliana siz1-2 due to positive-feedback regulation by salicylic acid. SIZ1 physically interacts with TPR1 and facilitates its SUMO modification. The K282 and K721 residues in TPR1 serve as critical SUMO attachment sites. Simultaneous introduction of K282R and K721R substitutions in TPR1 blocked its SUMOylation, enhanced its transcriptional co-repressor activity, and increased its association with HISTONE DEACETYLASE 19 (HDA19), suggesting that SUMOylation of TPR1 represses its transcriptional co-repressor activity and inhibits its interaction with HDA19. In agreement with this finding, the simultaneous introduction of K282R and K721R substitutions enhanced TPR1-mediated immunity, and the tpr1 mutation partially suppressed autoimmunity in siz1-2. These results demonstrate that SIZ1-mediated SUMOylation of TPR1 represses plant immunity, which at least partly contributes to the suppression of autoimmunity under nonpathogenic conditions to ensure proper plant development. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
| 电子版国际标准刊号 | 1752-9867 |
| 出版地 | CAMBRIDGE |
| WOS关键词 | TRANSCRIPTION FACTORS INTERACT ; SALICYLIC-ACID ; LIGASE SIZ1 ; RESISTANCE PROTEINS ; DISEASE RESISTANCE ; SUMO CONJUGATION ; ABSCISIC-ACID ; DIVERSE ARRAY ; MODIFIER ; SNC1 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000457568200016 |
| 资助机构 | Chinese Academy of SciencesChinese Academy of Sciences [XDA08010105] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31670186, 31471363] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/19456]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Korea Res Inst Biosci & Biotechnol, Biol Resource Ctr, Jeongeup 56212, South Korea 3.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, De,Lin, Xiao-Li,Kong, Xiangxiong,et al. SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis[J]. MOLECULAR PLANT,2019,12(2):215-228. |
| APA | Niu, De.,Lin, Xiao-Li.,Kong, Xiangxiong.,Qu, Gao-Ping.,Cai, Bin.,...&Jin, Jing Bo.(2019).SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis.MOLECULAR PLANT,12(2),215-228. |
| MLA | Niu, De,et al."SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis".MOLECULAR PLANT 12.2(2019):215-228. |
入库方式： OAI收割
来源：植物研究所
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