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PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis

文献类型：期刊论文

作者Li, Bin; Wang, Yan1; Zhang, Yuanyuan; Tian, Wenwen1; Chong, Kang; Jang, Jyan-Chyun; Wang, Lei1
刊名NUCLEIC ACIDS RESEARCH
出版日期2019
卷号47期号:10页码:5001-5015
ISSN号0305-1048
DOI10.1093/nar/gkz191
文献子类Article
英文摘要Circadian clock coordinates numerous plant growth and developmental processes including cell elongation in the hypocotyl, whether or not it modulates cell proliferation is largely unknown. Here we have found that Pseudo Response Regulators (PRRs), essential components of circadian core oscillators, affect root meristem cell proliferation mediated by Target Of Rapamycin (TOR) signaling. The null mutants of PRRs display much reduced sensitivities to sugar-activated TOR signaling. We have subsequently identified Tandem Zinc Finger 1, encoding a processing body localized RNA-binding protein, as a direct target repressed by PRRs in mediating TOR signaling. Multiple lines of biochemical and genetic evidence have demonstrated that TZF1 acts downstream of PRRs to attenuate TOR signaling. Furthermore, TZF1 could directly bind TOR mRNA via its tandem zinc finger motif to affect TOR mRNA stability. Our findings support a notion that PRR-TZF1-TOR molecular axis modulates root meristem cell proliferation by integrating both transcriptional and post-transcriptional regulatory mechanisms.
学科主题Biochemistry & Molecular Biology
出版地OXFORD
电子版国际标准刊号1362-4962
WOS关键词PSEUDO-RESPONSE REGULATORS ; CIRCADIAN CLOCK ; PLANT-GROWTH ; MUTANT REVEALS ; RNA-BINDING ; PROTEIN ; TARGET ; RAPAMYCIN ; PATHWAY ; STRESS
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000471248400015
出版者OXFORD UNIV PRESS
资助机构National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31570292] ; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDB27030206] ; Chinese Academy of SciencesChinese Academy of Sciences [QYZDB-SSW-SMC011] ; Ohio Agricultural Research and Development Center SEEDS grant [2018-007] ; NSFCNational Natural Science Foundation of China (NSFC) [31570292]
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/19701]  
专题中科院植物分子生理学重点实验室
作者单位1.Chinese Acad Sci, Key Lab Plant Mol Physiol, CAS Ctr Excellence Mol Plant Sci, Inst Bot, Beijing 10093, Peoples R China
2.Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA
3.Ohio State Univ, Dept Hort & Crop Sci, Columbus, OH 43210 USA
4.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Bin,Wang, Yan,Zhang, Yuanyuan,et al. PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis[J]. NUCLEIC ACIDS RESEARCH,2019,47(10):5001-5015.
APA Li, Bin.,Wang, Yan.,Zhang, Yuanyuan.,Tian, Wenwen.,Chong, Kang.,...&Wang, Lei.(2019).PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis.NUCLEIC ACIDS RESEARCH,47(10),5001-5015.
MLA Li, Bin,et al."PRR5, 7and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis".NUCLEIC ACIDS RESEARCH 47.10(2019):5001-5015.

入库方式： OAI收割

来源：植物研究所

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