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The Histone H3K4 Demethylase JMJ16 Represses Leaf Senescence in Arabidopsis

文献类型：期刊论文

作者Liu, Peng2; Zhang, Shuaibin6,7; Zhou, Bing8; Luo, Xi9; Zhou, Xiao Feng10; Cai, Bin; Jin, Yin Hua; Niu, De; Lin, Jinxing4; Cao, Xiaofeng1,5,6,7
刊名PLANT CELL
出版日期2019
卷号31期号:2页码:430-443
ISSN号1040-4651
DOI10.1105/tpc.18.00693
文献子类Article
英文摘要Leaf senescence is governed by a complex regulatory network involving the dynamic reprogramming of gene expression. Age-dependent induction of senescence-associated genes (SAGs) is associated with increased levels of trimethylation of histone H3 at Lys4 (H3K4me3), but the regulatory mechanism remains elusive. Here, we found that JMJ16, an Arabidopsis (Arabidopsis thaliana) JmjC-domain containing protein, is a specific H3K4 demethylase that negatively regulates leaf senescence through its enzymatic activity. Genome-wide analysis revealed a widespread coordinated upregulation of gene expression and hypermethylation of H3K4me3 at JMJ16 binding genes associated with leaf senescence in the loss-of-function jmj16 mutant as compared with the wild type. Genetic analysis indicated that JMJ16 negatively regulates leaf senescence, at least partly through repressing the expression of positive regulators of leaf senescence, WRKY53 and SAG201. JMJ16 associates with WRKY53 and SAG201 and represses their precocious expression in mature leaves by reducing H3K4me3 levels at these loci. The protein abundance of JMJ16 gradually decreases during aging, which is correlated with increased H3K4me3 levels at WRKY53 and SAG201, suggesting that the age-dependent downregulation of JMJ16 is required for the precise transcriptional activation of SAGs during leaf senescence. Thus, JMJ16 is an important regulator of leaf senescence that demethylates H3K4 at SAGs in an age-dependent manner.
学科主题Biochemistry & Molecular Biology ; Plant Sciences ; Cell Biology
出版地ROCKVILLE
电子版国际标准刊号1532-298X
WOS关键词DEPENDENT MANNER ; READ ALIGNMENT ; GENE ; WRKY53 ; METHYLATION ; TARGETS ; PROTEIN ; DEATH ; REF6 ; RPH1
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences ; Cell Biology
语种英语
WOS记录号WOS:000462028400015
出版者AMER SOC PLANT BIOLOGISTS
资助机构National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31788103, 91540203, 31471363] ; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDB27030201] ; Key Research Program of Frontier Sciences, Chinese Academy of Sciences [QYZDY-SSW-SMC022] ; Chinese Academy of Sciences (The Innovative Academy of Seed Design)
源URL[http://ir.ibcas.ac.cn/handle/2S10CLM1/19729]  
专题中科院植物分子生理学重点实验室
作者单位1.Beijing Forestry Univ, China Coll Biol Sci & Biotechnol, Beijing 100083, Peoples R China
2.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
3.King Abdullah Univ Sci & Technol, Div Biol Environm Sci & Engn, Thuwal, Saudi Arabia
4.China Agr Univ, Dept Ornamental Hort, Beijing 100193, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Inst Bot, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
7.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China
8.Chinese Acad Sci, Inst Genet & Dev Biol, Natl Ctr Plant Gene Res, Beijing 100101, Peoples R China
9.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China
10.Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Peng,Zhang, Shuaibin,Zhou, Bing,et al. The Histone H3K4 Demethylase JMJ16 Represses Leaf Senescence in Arabidopsis[J]. PLANT CELL,2019,31(2):430-443.
APA Liu, Peng.,Zhang, Shuaibin.,Zhou, Bing.,Luo, Xi.,Zhou, Xiao Feng.,...&Jin, Jing Bo.(2019).The Histone H3K4 Demethylase JMJ16 Represses Leaf Senescence in Arabidopsis.PLANT CELL,31(2),430-443.
MLA Liu, Peng,et al."The Histone H3K4 Demethylase JMJ16 Represses Leaf Senescence in Arabidopsis".PLANT CELL 31.2(2019):430-443.

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来源：植物研究所

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