片段/虚拟分子印迹聚合物的应用新进展
文献类型：期刊论文
| 作者 | 王艺晓1,2; 李金花1,2 ; 王莉燕1,2; 齐骥1; 陈令新1,2
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| 刊名 | 色谱
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| 出版日期 | 2021 |
| 卷号 | 39期号:2页码:134-141 |
| ISSN号 | 1000-8713 |
| 关键词 | 分子印迹聚合物 片段印迹 虚拟模板印迹 制备 应用 综述 |
| 其他题名 | Recent advances in applications of fragment/dummy molecularly imprinted polymers |
| 文献子类 | Review |
| 英文摘要 | Molecularly imprinted polymers (MIPs) are designed to mimic the specific binding principle of enzymes to substrates or antigens to antibodies,while holding several advantages such as structure predictability,recognition specificity,easy preparation,low cost,high physical robustness,and thermal stability.Therefore,they have been widely applied in many fields including sample preparation (pretreatment),sensing analysis (chemo/biosensors),biomedicine,and environment/food analysis.To date,several strategies were developed for MIPs preparation,aiming to simplify the preparation process and/or improve the properties of the polymers,greatly broadening its usability.The exploration in various advanced imprinting strategies and their combinational use has become a research hotspot in MIPs preparation,among which the fragment imprinting strategy and the dummy template imprinting strategy are especially favored.Fragment imprinting,also called segment imprinting,uses a partial structure of the target molecule as a pseudo-template to prepare MIPs.This strategy is useful to target molecules that are not easy to obtain or that are too large to be used as templates,providing a feasible method for imprinting target analytes that are easy to inactivate or infect,as well as macromolecules that are difficult to imprint.In turn,dummy template imprinting uses molecules with structure,shape,and size similar to the target analytes as templates for imprinting.Because the target is not directly used as a template,this strategy can overcome problems of template leakage,as well as solve target molecule-related difficulties as they can be expensive,infectious,flammable,explosive,or chemically instable.This mini-review compiles information of several articles published in the last four years across ACS,Elsevier,RSC,and other databases,summarizing the most recent advances in the application of fragment/dummy template MIPs (FMIPs/DMIPs).Herein,the biomedical application of FMIPs is mainly addressed as a strategy for the detection of proteins and microorganisms,and the application of FMIPs in the field of food analysis is also explored.In recent years,the imprinting of mammalian cells has made some progress in the application of FMIPs.Mammalian cells,especially cancer cells,overexpress some proteins and sugars,which are good fragment templates.Consequently,the fragment imprinting strategy is widely used in cancer cell imaging,localization,and treatment.Moreover,due to the complicated structure and easy inactivation of some proteins,their MIPs are often prepared by fragment imprinting (also called epitope imprinting).As some microorganisms are infectious,imprinting microorganisms directly can pose a risk;therefore it is safer to also use the fragment imprinting strategy in such cases.The recent application of fragment imprinting strategy in other areas remains scarce.Nonetheless,three studies in the food analysis have explored this possibility.DMIPs are widely used in sample pretreatment and sensing analysis,and they are mainly used as SPE adsorbents for packed SPE,dispersive SPE (DSPE),magnetic SPE (MSPE),and matrix solid phase dispersion (MSPD) extraction.In addition,DMIPs are employed as molecularly imprinted membrane materials.As a result,by virtue of DMIPs,selective extraction and enrichment of target analytes from complicated samples can be achieved.MIP-based sensors can either recognize or transduce,meaning that they can specifically recognize and bind target analytes as well as generate output signals for detection.Because of the high selectivity of MIPs,the use of a dummy template imprinting strategy solves the problem of template leakage in the process of recognition and adsorption,further improving the detection accuracy and sensitivity of the sensor.These features expand the application range of MIP-based sensors. |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6910569 |
| 资助机构 | 国家自然科学基金 ; 烟台市科技发展计划 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/30301]  |
| 专题 | 烟台海岸带研究所_山东省海岸带环境工程技术研究中心 |
| 作者单位 | 1.中国科学院烟台海岸带研究所,中国科学院海岸带环境过程与生态修复重点实验室,山东省海岸带环境过程重点实验室,海岸带环境工程技术研究与发展中心,山东烟台264003; 2.中国科学院大学资源与环境学院,北京100049 |
| 推荐引用方式 GB/T 7714 | 王艺晓,李金花,王莉燕,等. 片段/虚拟分子印迹聚合物的应用新进展[J]. 色谱,2021,39(2):134-141. |
| APA | 王艺晓,李金花,王莉燕,齐骥,&陈令新.(2021).片段/虚拟分子印迹聚合物的应用新进展.色谱,39(2),134-141. |
| MLA | 王艺晓,et al."片段/虚拟分子印迹聚合物的应用新进展".色谱 39.2(2021):134-141. |
入库方式： OAI收割
来源：烟台海岸带研究所
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