Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse
文献类型：期刊论文
| 作者 | Guo, Duancheng1,2; Wang, Yuan2; Cheng, Yan1; Liao, Shengyou5; Hu, Jian1; Du, Fang1; Xu, Gang1; Liu, Yongqiang1; Cai, Kathy Q.1; Cheung, Martin3 |
| 刊名 | JOURNAL OF EXPERIMENTAL MEDICINE
 |
| 出版日期 | 2021-09-06 |
| 卷号 | 218期号:9页码:22 |
| ISSN号 | 0022-1007 |
| DOI | 10.1084/jem.20202350 |
| 英文摘要 | Astrocytes, a major glial cell type in the brain, play a critical role in supporting the progression of medulloblastoma (MB), the most common malignant pediatric brain tumor. Through lineage tracing analyses and single-cell RNA sequencing, we demonstrate that astrocytes are predominantly derived from the transdifferentiation of tumor cells in relapsed MB (but not in primary MB), although MB cells are generally believed to be neuronal-lineage committed. Such transdifferentiation of MB cells relies on Sox9, a transcription factor critical for gliogenesis. Our studies further reveal that bone morphogenetic proteins (BMPs) stimulate the transdifferentiation of MB cells by inducing the phosphorylation of Sox9. Pharmacological inhibition of BMP signaling represses MB cell transdifferentiation into astrocytes and suppresses tumor relapse. Our studies establish the distinct cellular sources of astrocytes in primary and relapsed MB and provide an avenue to prevent and treat MB relapse by targeting tumor cell transdifferentiation. |
| 资助项目 | American Cancer Society[RSG1605301NEC] ; American Brain Tumor Association[DG1900025] ; Pennsylvania CURE Health Research Fund[CURE 4100068716] |
| WOS研究方向 | Immunology ; Research & Experimental Medicine |
| 语种 | 英语 |
| 出版者 | ROCKEFELLER UNIV PRESS |
| WOS记录号 | WOS:000701689900008 |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/17062]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Zhao, Yi; Yang, Zeng-jie |
| 作者单位 | 1.Temple Univ Hlth Syst, Fox Chase Canc Ctr, Canc Biol Program, Philadelphia, PA 19140 USA 2.Soochow Univ, Coll Pharmaceut Sci, Pediat Canc Ctr, Suzhou, Peoples R China 3.Univ Hong Kong, Sch Biomed Sci, Li Ka Shing Fac Med, Hong Kong, Peoples R China 4.Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia 5.Chinese Acad Sci, Inst Comp Technol, Adv Comp Res Ctr, Key Lab Intelligent Informat Proc, Beijing, Peoples R China 6.Cincinnati Childrens Hosp Med Ctr, Brain Tumor Ctr, Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA |
| 推荐引用方式 GB/T 7714 | Guo, Duancheng,Wang, Yuan,Cheng, Yan,et al. Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2021,218(9):22. |
| APA | Guo, Duancheng.,Wang, Yuan.,Cheng, Yan.,Liao, Shengyou.,Hu, Jian.,...&Yang, Zeng-jie.(2021).Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse.JOURNAL OF EXPERIMENTAL MEDICINE,218(9),22. |
| MLA | Guo, Duancheng,et al."Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse".JOURNAL OF EXPERIMENTAL MEDICINE 218.9(2021):22. |
入库方式： OAI收割
来源：计算技术研究所
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