Characterization of whole-brain task-modulated functional connectivity in response to nociceptive pain: A multisensory comparison study
文献类型：期刊论文
| 作者 | Li, Linling2,3; Di, Xin4; Zhang, Huijuan5,6; Huang, Gan2,3; Zhang, Li2,3 ; Liang, Zhen2,3; Zhang, Zhiguo1,2,3
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| 刊名 | HUMAN BRAIN MAPPING
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| 出版日期 | 2021-11-11 |
| 页码 | 15 |
| 关键词 | functional connectivity MRI neuroimaging pain psychophysiological interaction task |
| ISSN号 | 1065-9471 |
| DOI | 10.1002/hbm.25707 |
| 通讯作者 | Zhang, Zhiguo(zgzhang@szu.edu.cn) |
| 英文摘要 | Previous functional magnetic resonance imaging (fMRI) studies have shown that brain responses to nociceptive pain, non-nociceptive somatosensory, visual, and auditory stimuli are extremely similar. Actually, perception of external sensory stimulation requires complex interactions among distributed cortical and subcortical brain regions. However, the interactions among these regions elicited by nociceptive pain remain unclear, which limits our understanding of mechanisms of pain from a brain network perspective. Task fMRI data were collected with a random sequence of intermixed stimuli of four sensory modalities in 80 healthy subjects. Whole-brain psychophysiological interaction analysis was performed to identify task-modulated functional connectivity (FC) patterns for each modality. Task-modulated FC strength and graph-theoretical-based network properties were compared among the four modalities. Lastly, we performed across-sensory-modality prediction analysis based on the whole-brain task-modulated FC patterns to confirm the specific relationship between brain patterns and sensory modalities. For each sensory modality, task-modulated FC patterns were distributed over widespread brain regions beyond those typically activated or deactivated during the stimulation. As compared with the other three sensory modalities, nociceptive stimulation exhibited significantly different patterns (more widespread and stronger FC within the cingulo-opercular network, between cingulo-opercular and sensorimotor networks, between cingulo-opercular and emotional networks, and between default mode and emotional networks) and global property (smaller modularity). Further, a cross-sensory-modality prediction analysis found that task-modulated FC patterns could predict sensory modality at the subject level successfully. Collectively, these results demonstrated that the whole-brain task-modulated FC is preferentially modulated by pain, thus providing new insights into the neural mechanisms of pain processing. |
| 收录类别 | SCI |
| WOS关键词 | FALSE DISCOVERY RATE ; DEFAULT-MODE ; PSYCHOPHYSIOLOGICAL INTERACTIONS ; SOMATOSENSORY INFORMATION ; GLOBAL SIGNAL ; NETWORKS ; ATTENTION ; PERCEPTION ; DYNAMICS ; AMYGDALA |
| 资助项目 | National Natural Science Foundation of China[81901831] ; National Natural Science Foundation of China[81871443] ; Natural Science Foundation of Guangdong Province, China[2021A1515011152] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[2021SHIBS0003] |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000716886400001 |
| 出版者 | WILEY |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions |
| 源URL | [http://ir.psych.ac.cn/handle/311026/41010]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Zhiguo |
| 作者单位 | 1.Peng Cheng Lab, Shenzhen, Peoples R China 2.Shenzhen Univ, Sch Biomed Engn, Hlth Sci Ctr, Shenzhen, Peoples R China 3.Guangdong Prov Key Lab Biomed Measurements & Ultr, Shenzhen, Peoples R China 4.New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Linling,Di, Xin,Zhang, Huijuan,et al. Characterization of whole-brain task-modulated functional connectivity in response to nociceptive pain: A multisensory comparison study[J]. HUMAN BRAIN MAPPING,2021:15. |
| APA | Li, Linling.,Di, Xin.,Zhang, Huijuan.,Huang, Gan.,Zhang, Li.,...&Zhang, Zhiguo.(2021).Characterization of whole-brain task-modulated functional connectivity in response to nociceptive pain: A multisensory comparison study.HUMAN BRAIN MAPPING,15. |
| MLA | Li, Linling,et al."Characterization of whole-brain task-modulated functional connectivity in response to nociceptive pain: A multisensory comparison study".HUMAN BRAIN MAPPING (2021):15. |
入库方式： OAI收割
来源：心理研究所
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