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Smoking Affects the Patterns of Metabolic Disorders and Metabolic Syndrome in Patients With First-Episode Drug-Naive Schizophrenia: A Large Sample Study Based on the Chinese Han Population

文献类型：期刊论文

作者Li, Zezhi1,7; Wang, Shuning2; Chen, Yuping2; Wu, Xi7; Gu, Yinjun4; Lang, Xiaoe5; Wu, Fengchun3; Zhang, Xiang Yang6,7
刊名INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
出版日期2021-10-01
卷号24期号:10页码:798-807
关键词Metabolic disorders metabolic syndrome schizophrenia smoking
ISSN号1461-1457
DOI10.1093/ijnp/pyab038
通讯作者Wu, Fengchun(13580380071@163.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
英文摘要Objective Although metabolic disorders and smoking are common in schizophrenia, few studies have investigated the effects of smoking on metabolic disorders or metabolic syndrome (MetS) in schizophrenia patients, especially in first-episode drug-naive (FEDN) patients. We sought to investigate the differences in metabolic disorders and MetS between smoking and nonsmoking FEDN schizophrenia patients. Methods A total of 428 FEDN schizophrenia patients and 435 controls were recruited. Blood pressure, waist circumference, body mass index (BMI), lipid profiles, and glucose metabolism were measured. The psychopathology was evaluated by Positive and Negative Syndrome Scale. Results FEDN schizophrenia patients had a higher smoking rate than controls (23.8% vs 14.0%, P<.001). After adjusting for confounding variables, the prevalence of MetS, overweight, hypertension, hypertriglyceridemia, elevated insulin, and insulin resistance in smoking patients was higher than those in nonsmoking patients, while overweight and hypertension were higher in the smoking controls than in nonsmoking controls (all P<.05). In smoking patients, triglyceridemia, high-density lipoprotein cholesterol, and fasting blood glucose were the main contributing components to MetS, while in nonsmoking patients, waist circumference, systolic blood pressure, triglyceridemia, high-density lipoprotein cholesterol, and fasting blood glucose were the main contributing components to MetS. In smoking patients, BMI and homeostatic model assessment for insulin resistance were associated factors of MetS (both P<.05). In nonsmoking patients, sex, BMI, insulin, and homeostatic model assessment for insulin resistance were associated factors of MetS (all P<.05). Conclusions Our study indicates that smoking schizophrenia patients have a higher prevalence of MetS and metabolic disorders than nonsmoking patients. Moreover, smoking and nonsmoking patients have different contributing components and associated factors for MetS.
收录类别SCI
WOS关键词MAJOR DEPRESSIVE DISORDER ; GENOME-WIDE ASSOCIATION ; BIPOLAR DISORDER ; NICOTINE DEPENDENCE ; PSYCHOTIC DISORDERS ; RISK ; VARIANTS ; TOBACCO ; PEOPLE ; DISTURBANCE
资助项目National Natural Science Foundation of China[81401127] ; Science and Technology Program of Guangzhou[201807010064] ; Shanghai Jiao Tong University Medical Engineering Foundation[YG2016MS48] ; Shanghai Jiao Tong University School of Medicine[19XJ11006]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
WOS记录号WOS:000715357800004
出版者OXFORD UNIV PRESS
资助机构National Natural Science Foundation of China ; Science and Technology Program of Guangzhou ; Shanghai Jiao Tong University Medical Engineering Foundation ; Shanghai Jiao Tong University School of Medicine
源URL[http://ir.psych.ac.cn/handle/311026/41019]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wu, Fengchun; Zhang, Xiang Yang
作者单位1.Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Neurol, Sch Med, Shanghai, Peoples R China
2.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China
3.Shanghai Changhai Hosp, Dept Neurosurg, Shanghai, Peoples R China
4.Jinshan Mental Hlth Ctr, Shanghai, Peoples R China
5.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Peoples R China
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
7.Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zezhi,Wang, Shuning,Chen, Yuping,et al. Smoking Affects the Patterns of Metabolic Disorders and Metabolic Syndrome in Patients With First-Episode Drug-Naive Schizophrenia: A Large Sample Study Based on the Chinese Han Population[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2021,24(10):798-807.
APA Li, Zezhi.,Wang, Shuning.,Chen, Yuping.,Wu, Xi.,Gu, Yinjun.,...&Zhang, Xiang Yang.(2021).Smoking Affects the Patterns of Metabolic Disorders and Metabolic Syndrome in Patients With First-Episode Drug-Naive Schizophrenia: A Large Sample Study Based on the Chinese Han Population.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,24(10),798-807.
MLA Li, Zezhi,et al."Smoking Affects the Patterns of Metabolic Disorders and Metabolic Syndrome in Patients With First-Episode Drug-Naive Schizophrenia: A Large Sample Study Based on the Chinese Han Population".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 24.10(2021):798-807.

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来源：心理研究所

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