Prevalence and clinical correlates of impaired glucose tolerance in first-episode versus chronic patients with schizophrenia
文献类型：期刊论文
| 作者 | Li, Shen1,2; Chen, Dachun3; Xiu, Meihong3; Li, Jie2 ; Zhang, Xiang Yang4,5
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| 刊名 | EARLY INTERVENTION IN PSYCHIATRY
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| 出版日期 | 2021-11-07 |
| 页码 | 9 |
| 关键词 | drug naive first episode impaired glucose tolerance schizophrenia |
| ISSN号 | 1751-7885 |
| DOI | 10.1111/eip.13240 |
| 通讯作者 | Li, Jie(jieli@tjmhc.com) ; Zhang, Xiang Yang(zhangxy@psych.ac) |
| 英文摘要 | Aim Studies using oral glucose tolerance tests (OGTT) have shown that impaired glucose metabolism presents in the early stages of schizophrenia (SCZ). However, there is a lack of studies on changes in glucose metabolism with the stage of the disease. We first explored the features of glucose metabolic pattern at different phases of male SCZ. Methods We recruited 83 male first episode drug-naive patients with SCZ (FEDN-SCZ) and 64 male chronic patients with SCZ (CH-SCZ), as well as 14 male healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to assess the psychopathology of patients. OGTT, fasting plasma glucose and lipid profiles of all participants were examined. Results While the impaired glucose tolerance (IGT) rate of male SCZ patients was higher than that of HC (P < .05), there was no difference in IGT prevalence between FEDN-SCZ and CH-SCZ. In male FEDN-SCZ, LDL (OR = 2.64, 95% CI = 1.11-6.29, P = .028) and PANSS total score (OR = 1.03, 95% CI = 1.00-1.06, P = .046) were positively correlated with IGT; in male CH-SCZ, BMI (OR = 1.7, 95% CI = 1.08-2.67, P = .023), PANSS total score (OR = 0.82, 95% CI = 0.70-0.96, P = .015) and positive symptoms (OR = 0.45, 95% CI = 0.20-0.99, P = .046) were significantly correlated with IGT. Conclusions Our findings reflect different glucose metabolism patterns in different stages of SCZ. |
| 收录类别 | SCI |
| WOS关键词 | DRUG-NAIVE PATIENTS ; NEGATIVE SYNDROME SCALE ; BODY-MASS INDEX ; DIABETES-MELLITUS ; GENDER-DIFFERENCES ; METABOLIC SYNDROME ; FASTING GLUCOSE ; INSULIN-RESISTANCE ; HOMEOSTASIS ; MORTALITY |
| 资助项目 | National Natural Science Foundation of China[81801323] ; Tianjin Key Project for Chronic Disease Prevention[17ZXMFSY00070] ; Tianjin Key Discipline Project for Psychiatry |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000715069900001 |
| 出版者 | WILEY |
| 资助机构 | National Natural Science Foundation of China ; Tianjin Key Project for Chronic Disease Prevention ; Tianjin Key Discipline Project for Psychiatry |
| 源URL | [http://ir.psych.ac.cn/handle/311026/41022]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Li, Jie; Zhang, Xiang Yang |
| 作者单位 | 1.Tianjin Med Univ, Coll Basic Med Sci, Dept Psychiat, Tianjin, Peoples R China 2.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Lab Biol Psychiat, Tianjin, Peoples R China 3.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shen,Chen, Dachun,Xiu, Meihong,et al. Prevalence and clinical correlates of impaired glucose tolerance in first-episode versus chronic patients with schizophrenia[J]. EARLY INTERVENTION IN PSYCHIATRY,2021:9. |
| APA | Li, Shen,Chen, Dachun,Xiu, Meihong,Li, Jie,&Zhang, Xiang Yang.(2021).Prevalence and clinical correlates of impaired glucose tolerance in first-episode versus chronic patients with schizophrenia.EARLY INTERVENTION IN PSYCHIATRY,9. |
| MLA | Li, Shen,et al."Prevalence and clinical correlates of impaired glucose tolerance in first-episode versus chronic patients with schizophrenia".EARLY INTERVENTION IN PSYCHIATRY (2021):9. |
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来源：心理研究所
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