Prevalence, clinical correlates and risk factors associated with Tardive Dyskinesia in Chinese patients with schizophrenia
文献类型：期刊论文
| 作者 | Uludag, Kadir2,3; Wang, Dong Mei2,3 ; Goodman, Colin1; Chen, Da Chun4; Wang, Li2,3; Zhang, Xiangyang2,3
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| 刊名 | ASIAN JOURNAL OF PSYCHIATRY
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| 出版日期 | 2021-12-01 |
| 卷号 | 66页码:6 |
| 关键词 | Schizophrenia Tardive Dyskinesia Prevalence Risk factors |
| ISSN号 | 1876-2018 |
| DOI | 10.1016/j.ajp.2021.102877 |
| 通讯作者 | Wang, Dong Mei(wangdm@psych.ac.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | Tardive Dyskinesia (TD) is a serious, nonrhythmic and iatrogenic movement disorder, and is a common comorbidity in patients with schizophrenia (SZ). The main goal of this study was to investigate the prevalence, clinical correlates, and risk factors of TD in Chinese patients with chronic SZ, which has not been fully studied. This study adopted a cross-sectional design. A total of 901 Chinese inpatients with SZ were recruited between 2008 and 2011. We used the Abnormal Involuntary Movement Scale (AIMS) to measure the severity of TD, and the Positive and Negative Syndrome Scale (PANSS) was used to measure the psychopathological symptoms of SZ. Blood samples were also collected for routine blood tests, including the levels of triglyceride (TG), cholesterol (CHO), HDL-cholesterol (HDL-CHO), LDL-cholesterol (LDL-CHO), Apolipoprotein A1 (ApoA1), and Apolipoprotein B (ApoB). Overall, 36% of patients with SZ had TD. Compared with the non-TD patients, the TD patients were more likely to be men, had older age, lower education level, higher smoking rate, higher hospitalization frequency, and longer duration of illness (DOI). Further, compared with the non-TD patients, the TD patients had higher PANSS total, PANSS negative subscale, and cognitive subscale scores, but had lower depressive subscale scores and lower mean levels of metabolic biomarkers, including TG, CHO, HDL-CHO, LDL-CHO, ApoA1 and ApoB. Moreover, binary regression analysis showed that antipsychotic type, BMI, gender, age, HDL-CHO, and ApoB were associated with TD. Our findings indicate that TD is a common movement disorder in patients with chronic SZ, with certain demographic and clinical variables being risk factors for the development of TD. |
| 收录类别 | SCI |
| WOS关键词 | NEGATIVE SYNDROME SCALE ; AIR-POLLUTION ; SMOKING ; ANTIPSYCHOTICS ; DEPRESSION ; INPATIENTS ; SYMPTOMS ; GENDER ; ONSET ; PANSS |
| 资助项目 | CAS International Cooperation Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health ; Chinese government |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000712277500016 |
| 出版者 | ELSEVIER |
| 资助机构 | CAS International Cooperation Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health ; Chinese government |
| 源URL | [http://ir.psych.ac.cn/handle/311026/41091]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wang, Dong Mei; Zhang, Xiangyang |
| 作者单位 | 1.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Beijing HuiLongGuan Hosp, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Uludag, Kadir,Wang, Dong Mei,Goodman, Colin,et al. Prevalence, clinical correlates and risk factors associated with Tardive Dyskinesia in Chinese patients with schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2021,66:6. |
| APA | Uludag, Kadir,Wang, Dong Mei,Goodman, Colin,Chen, Da Chun,Wang, Li,&Zhang, Xiangyang.(2021).Prevalence, clinical correlates and risk factors associated with Tardive Dyskinesia in Chinese patients with schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,66,6. |
| MLA | Uludag, Kadir,et al."Prevalence, clinical correlates and risk factors associated with Tardive Dyskinesia in Chinese patients with schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 66(2021):6. |
入库方式： OAI收割
来源：心理研究所
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