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Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits

文献类型：期刊论文

作者Huo,Lijuan3,4; Lu,Xiaobing3,4; Wu,Fengchun3,4; Chang,Catherine5; Ning,Yuping2,3,4; Zhang,Xiang Yang1,4
刊名BMC Psychiatry
出版日期2021-12-04
卷号21期号:1页码:10
关键词Geriatric schizophrenia Oxidative stress Plasma Cognition Negative symptoms
DOI10.1186/s12888-021-03604-5
通讯作者Zhang,Xiang Yang(zhangxy@psych.ac.cn)
英文摘要AbstractBackgroundDespite inconsistent findings, accumulative evidence has shown abnormalities of the key antioxidant enzyme, superoxide dismutase (SOD), in patients with schizophrenia. However, few studies explored SOD in late-life schizophrenia (LLS). Our work aimed to investigate changes in SOD activity and the relationship between SOD activity and psychotic symptoms or cognitive deficits in LLS.Methods32 geriatric male patients with schizophrenia (age?≥?60) and 28 age-matched male normal controls were recruited in the study. We assessed cognitive functions with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), evaluated the severity of clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), and measured the plasma levels of SOD.ResultsPatients with LLS presented with higher total levels of SOD compared to the controls (81.70 vs. 65.26?U/ml, p?
收录类别SCI
WOS关键词ANTIOXIDANT DEFENSE SYSTEMS ; ACID REACTIVE SUBSTANCES ; DRUG-NAIVE PATIENTS ; OXIDATIVE STRESS ; LIPID-PEROXIDATION ; NEUROPSYCHOLOGICAL PERFORMANCE ; NEGATIVE SYMPTOMS ; BIPOLAR DISORDER ; DNA-DAMAGE ; IMPAIRMENT
资助项目National Natural Science Foundation of China[82102673] ; Science and Technology Plan Project of Guangdong Province, China[2019B030316001] ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory, Science and Technology Program of Guangzhou, China[201805010009] ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory, Science and Technology Program of Guangzhou, China[201807010064]
WOS研究方向Psychiatry
语种英语
WOS记录号BMC:10.1186/S12888-021-03604-5
出版者BioMed Central
资助机构National Natural Science Foundation of China ; Science and Technology Plan Project of Guangdong Province, China ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory, Science and Technology Program of Guangzhou, China
源URL[http://ir.psych.ac.cn/handle/311026/41095]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang,Xiang Yang
作者单位1.Institute of Psychology, Chinese Academy of Sciences; CAS Key Laboratory of Mental Health
2.Southern Medical University; The First School of Clinical Medicine
3.Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders
4.Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital); Department of Psychiatry
5.The University of Texas Health Science Center at Houston; Department of Psychiatry and Behavioral Sciences
推荐引用方式
GB/T 7714		 Huo,Lijuan,Lu,Xiaobing,Wu,Fengchun,et al. Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits[J]. BMC Psychiatry,2021,21(1):10.
APA Huo,Lijuan,Lu,Xiaobing,Wu,Fengchun,Chang,Catherine,Ning,Yuping,&Zhang,Xiang Yang.(2021).Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits.BMC Psychiatry,21(1),10.
MLA Huo,Lijuan,et al."Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits".BMC Psychiatry 21.1(2021):10.

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来源：心理研究所

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