Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study
文献类型：期刊论文
| 作者 | Wang, Ling-Ling1,4,5; Lam, Christina Y. T.3; Huang, Jia1,4,5 ; Cheung, Eric F. C.3; Lui, Simon S. Y.2,3; Chan, Raymond C. K.1,4,5
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| 刊名 | SCHIZOPHRENIA BULLETIN
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| 出版日期 | 2021-11-01 |
| 卷号 | 47期号:6页码:1524-1533 |
| 关键词 | range adaptive coding range adaptation value representation amotivation schizophrenia |
| ISSN号 | 0586-7614 |
| DOI | 10.1093/schbul/sbab099 |
| 通讯作者 | Chan, Raymond C. K.(rckchan@psych.ac.cn) |
| 英文摘要 | Amotivation is related to value representation. A comprehensive account of amotivation requires a mechanistic understanding of how the brain exploits external information to represent value. To achieve maximal value discriminability, brain valuation system will dynamically adapt its coding sensitivity to the range of values available in any given condition, so-called range adaptive coding. We administered an experimental task to 30 patients with chronic schizophrenia (C-SCZ), 30 first-episode schizophrenia (FE-SCZ), 34 individuals with high social anhedonia (HSoA), and their paired controls to assess range adaptation ability. C-SCZ patients exhibited over-adaptation and their performances were negatively correlated with avolition symptoms and positive symptoms and positively correlated with blunted-affect symptoms and self-reported consummatory interpersonal pleasure scores, though the results were non-significant. FE-SCZ patients exhibited reduced adaptation, which was significantly and negatively correlated with avolition symptoms and positively correlated with the overall proportion of choosing to exert more effort. Although HSoA participants exhibited comparable range adaptation to controls, their performances were significantly and negatively correlated with the proportion of choosing to exert more effort under the lowest value condition. Our results suggest that different stages of schizophrenia spectrum showed distinct range adaptation patterns. Range adaptation impairments may index a possible underlying mechanism for amotivation symptoms in FE-SCZ and more complicated and pervasive effects on clinical symptoms in C-SCZ. |
| 收录类别 | SCI |
| WOS关键词 | NEGATIVE SYMPTOMS ; HUMAN MIDBRAIN ; DEFICITS ; ADAPTATION ; PREDICTION ; NEUROECONOMICS ; NEUROSCIENCE ; INDIVIDUALS ; MOTIVATION ; PSYCHOSIS |
| 资助项目 | National Key Research and Development Programme[2016YFC0906402] ; Jiangsu Provincial Key Research and Development Program[BE2020661] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; CAS Key Laboratory of Mental Health, Institute of Psychology |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000715376600005 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | National Key Research and Development Programme ; Jiangsu Provincial Key Research and Development Program ; Beijing Municipal Science & Technology Commission Grant ; CAS Key Laboratory of Mental Health, Institute of Psychology |
| 源URL | [http://ir.psych.ac.cn/handle/311026/41236]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Chan, Raymond C. K. |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China 3.Castle Peak Hosp, Hong Kong, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ling-Ling,Lam, Christina Y. T.,Huang, Jia,et al. Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study[J]. SCHIZOPHRENIA BULLETIN,2021,47(6):1524-1533. |
| APA | Wang, Ling-Ling,Lam, Christina Y. T.,Huang, Jia,Cheung, Eric F. C.,Lui, Simon S. Y.,&Chan, Raymond C. K..(2021).Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study.SCHIZOPHRENIA BULLETIN,47(6),1524-1533. |
| MLA | Wang, Ling-Ling,et al."Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study".SCHIZOPHRENIA BULLETIN 47.6(2021):1524-1533. |
入库方式： OAI收割
来源：心理研究所
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