The relationship between cognitive impairment and superoxide dismutase activity in untreated first-episode patients with schizophrenia
文献类型：期刊论文
| 作者 | Wang, Dong Mei1,2; Du, Yu Xuan1,2; Zhu, Rong Rong1,2; Tian, Yang1,2; Chen, Jia Jing1,2; Chen, Da Chun3; Wang, Li1,2 ; Zhang, Xiang Yang1,2
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| 刊名 | WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
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| 出版日期 | 2021-12-17 |
| 页码 | 8 |
| 关键词 | Schizophrenia cognition superoxide dismutase first-episode oxidative stress |
| ISSN号 | 1562-2975 |
| DOI | 10.1080/15622975.2021.2013093 |
| 通讯作者 | Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Objectives: Cognitive decline is an essential characteristic of schizophrenia and may be due to the disturbance between reactive oxygen species generation and antioxidant capacity. The study aimed to explore the association between cognitive deficits and antioxidant defence parameters in untreated first-episode patients with schizophrenia. Methods: We determined important antioxidant enzymes, total superoxide dismutase (SOD) and manganese SOD (MnSOD), and their relationship with cognitive impairment in 168 untreated patients with first-episode schizophrenia and 168 age- and sex-matched healthy controls. The evaluation of psychopathological symptoms of all patients was based on the Positive and Negative Syndrome Scale (PANSS). We measured cognitive function by the Repeated Battery for the Assessment of Neuropsychological Status (RBANS) and activities of total SOD and MnSOD in all participants. Results: The results showed that untreated patients with first-episode schizophrenia had deficient cognitive functioning in four RBANS indices and total scores, except for the visuospatial/constructional index, as well as higher plasma total SOD activity compared with the control subjects. In addition, significant negative correlations were identified between MnSOD activity and attention index or RBANS total score in patients. Conclusions: Our results suggest that oxidative stress may be partly responsible for cognitive dysfunction in the early course of schizophrenia. |
| 收录类别 | SCI |
| WOS关键词 | LONG-TERM POTENTIATION ; MEDIATED IMMUNE ACTIVATION ; OXIDATIVE STRESS ; ASSOCIATION ; DEFICITS ; DYSFUNCTION ; PATHWAYS |
| 资助项目 | National Key Research and Development Program of China[2017YFC1310405] ; CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China[81371477] ; CAS Key Lab of Mental Health |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000731235300001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | National Key Research and Development Program of China ; CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China ; CAS Key Lab of Mental Health |
| 源URL | [http://ir.psych.ac.cn/handle/311026/41516]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang Yang |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Beijing Hui Long Guan Hosp, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dong Mei,Du, Yu Xuan,Zhu, Rong Rong,et al. The relationship between cognitive impairment and superoxide dismutase activity in untreated first-episode patients with schizophrenia[J]. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,2021:8. |
| APA | Wang, Dong Mei.,Du, Yu Xuan.,Zhu, Rong Rong.,Tian, Yang.,Chen, Jia Jing.,...&Zhang, Xiang Yang.(2021).The relationship between cognitive impairment and superoxide dismutase activity in untreated first-episode patients with schizophrenia.WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,8. |
| MLA | Wang, Dong Mei,et al."The relationship between cognitive impairment and superoxide dismutase activity in untreated first-episode patients with schizophrenia".WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2021):8. |
入库方式： OAI收割
来源：心理研究所
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