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Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

文献类型：期刊论文

作者Rao, Wenwang4,5; Meng, Xiangfei4,5; Li, Keqing1,3; Zhang, Yunshu1,3; Zhang, Xiang Yang2
刊名ANNALS OF GENERAL PSYCHIATRY
出版日期2021-12-20
卷号20期号:1页码:11
关键词Apolipoprotein A1 Apolipoprotein B Apolipoprotein E Clinical symptoms Schizophrenia
DOI10.1186/s12991-021-00376-w
通讯作者Zhang, Yunshu(zhangxy@psych.ac.cn) ; Zhang, Xiang Yang(yunshucoffee@sina.com)
英文摘要Background The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of schizophrenia and to explore the relationship between apolipoproteins levels and clinical symptoms. Methods The ApoE rs429358 was genotyped using a case-control design. The Positive and Negative Syndrome Scale (PANSS) was employed to evaluate the psychopathology of all patients. Results A total of 637 patients with schizophrenia and 467 healthy controls were recruited. We found no significant differences in the genotype and allele distribution between the patient and control groups. A significant correlation between PANSS negative symptoms and ApoA1 levels (p = 0.048) or ApoB levels (p = 0.001) was found in patients with schizophrenia, which was also confirmed by linear regression analyses (p = 0.048 vs. p = 0.001). Interestingly, only in the T homozygote group, ApoA1 and ApoB levels were predictors of the PANSS negative symptom score (p = 0.008 vs. p = 0.012), while in the C allele carrier group, no correlation was observed. Conclusions This study found that the levels of ApoA1 and ApoB were negatively associated with negative symptoms of patients with schizophrenia. Furthermore, the association between ApoA1 or ApoB levels and psychopathology of schizophrenia was regulated by ApoE rs429358.
收录类别SCI
WOS关键词E POLYMORPHISM ; EPSILON-4 ALLELE ; LIPID PROFILES ; APOE GENE ; RISK ; PREVALENCE ; DISEASE ; CHINESE ; BRAIN ; PSYCHOPATHOLOGY
资助项目National Natural Science Foundation of China[81371477] ; Key R&D Program of Science and Technology Department of Hebei Province[172777223] ; Government-funded Subsidy Project for Specialty Capacity-Building and Specialist Leaders[361014]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000732943500001
出版者BMC
资助机构National Natural Science Foundation of China ; Key R&D Program of Science and Technology Department of Hebei Province ; Government-funded Subsidy Project for Specialty Capacity-Building and Specialist Leaders
源URL[http://ir.psych.ac.cn/handle/311026/41519]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhang, Yunshu; Zhang, Xiang Yang
作者单位1.Hebei Psychiat Hosp, Dept Sleep Med, Shahe, Hebei, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lin Cui Rd, Beijing 100101, Peoples R China
3.Hebei Mental Hlth Ctr, Inst Mental Hlth, Baoding, Hebei, Peoples R China
4.McGill Univ, Fac Med & Hlth Sci, Dept Psychiat, Montreal, PQ, Canada
5.Douglas Mental Hlth Univ Inst, Mental Hlth & Soc Div, Montreal, PQ, Canada
推荐引用方式
GB/T 7714		 Rao, Wenwang,Meng, Xiangfei,Li, Keqing,et al. Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia[J]. ANNALS OF GENERAL PSYCHIATRY,2021,20(1):11.
APA Rao, Wenwang,Meng, Xiangfei,Li, Keqing,Zhang, Yunshu,&Zhang, Xiang Yang.(2021).Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia.ANNALS OF GENERAL PSYCHIATRY,20(1),11.
MLA Rao, Wenwang,et al."Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia".ANNALS OF GENERAL PSYCHIATRY 20.1(2021):11.

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来源：心理研究所

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