Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study
文献类型:期刊论文
作者 | Kirschner, Matthias1,37; Hodzic-Santor, Benazir37; Antoniades, Mathilde36; Nenadic, Igor35; Kircher, Tilo35; Krug, Axel34,35; Meller, Tina35; Grotegerd, Dominik33; Fornito, Alex32; Arnatkeviciute, Aurina32 |
刊名 | MOLECULAR PSYCHIATRY |
出版日期 | 2021-10-27 |
页码 | 10 |
ISSN号 | 1359-4184 |
DOI | 10.1038/s41380-021-01359-9 |
英文摘要 | Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r = 0.067, p(FDR) = 0.02). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r = 0.285, p(spin) = 0.024), but not BD (r = 0.166, p(spin) = 0.205) or MDD (r = -0.274, p(spin) = 0.073). The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho = -0.690, p(spin) = 0.006), BD (rho = -0.672, p(spin) = 0.009), and MDD (rho = -0.692, p(spin) = 0.004). Comprehensive mapping of schizotypy-related brain morphometry in the general population revealed a significant relationship between higher schizotypy and thicker mOFC/vmPFC, in the absence of confounding effects due to antipsychotic medication or disease chronicity. The cortical pattern similarity between schizotypy and schizophrenia yields new insights into a dimensional neurobiological continuity across the extended psychosis phenotype. |
收录类别 | SCI |
WOS关键词 | CLINICAL HIGH-RISK ; STRUCTURAL ABNORMALITIES ; HEALTHY-INDIVIDUALS ; PSYCHOSIS PRONENESS ; CEREBRAL-CORTEX ; BRAIN STRUCTURE ; MATTER CHANGES ; SCHIZOPHRENIA ; THICKNESS ; VOLUME |
资助项目 | NIH Big Data to Knowledge (BD2K) program under consortium[U54 EB020403] ; Wellcome Trust [Sir Henry Dale Fellowship][202397/Z/16/Z] ; Swiss National Science Foundation[P2SKP3_178175] |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
出版者 | SPRINGERNATURE |
WOS记录号 | WOS:000712489500001 |
资助机构 | NIH Big Data to Knowledge (BD2K) program under consortium ; Wellcome Trust [Sir Henry Dale Fellowship] ; Swiss National Science Foundation |
源URL | [http://ir.psych.ac.cn/handle/311026/40868] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Modinos, Gemma |
作者单位 | 1.Univ Zurich, Psychiat Hosp, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland 2.Kings Coll London, MRC Ctr Neurodev Disorders, London, England 3.Univ Southern Calif, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med, Marina, GA USA 4.Georgia State Univ, Imaging Genet & Neuroinformat Lab, Atlanta, GA 30303 USA 5.Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92717 USA 6.Univ Calif Irvine, Dept Psychiat & Human Behav, Clin Translat Neurosci Lab, Irvine, CA 92717 USA 7.Fresenius Univ Appl Sci, Frankfurt, Germany 8.City Univ London, London, England 9.Geneva Univ Hosp, Dept Psychiat, Geneva, Switzerland 10.Mental Hlth Res Ctr, Moscow, Russia |
推荐引用方式 GB/T 7714 | Kirschner, Matthias,Hodzic-Santor, Benazir,Antoniades, Mathilde,et al. Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study[J]. MOLECULAR PSYCHIATRY,2021:10. |
APA | Kirschner, Matthias.,Hodzic-Santor, Benazir.,Antoniades, Mathilde.,Nenadic, Igor.,Kircher, Tilo.,...&Modinos, Gemma.(2021).Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.MOLECULAR PSYCHIATRY,10. |
MLA | Kirschner, Matthias,et al."Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study".MOLECULAR PSYCHIATRY (2021):10. |
入库方式: OAI收割
来源:心理研究所
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