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Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy

文献类型：期刊论文

作者Gao, Jian4,5,6; Yang, Xiangyun4,5,6; Chen, Xiongying4,5,6; Liu, Rui4,5,6; Wang, Pengchong4,5,6; Meng, Fanqiang4,5,6; Li, Zhanjiang4,5,6; Zhou, Yuan1,2,3,4,5
刊名JOURNAL OF PSYCHIATRY & NEUROSCIENCE
出版日期2021-11-16
卷号46期号:6页码:E628-E638
ISSN号1180-4882
DOI10.1503/jpn.210084
通讯作者Li, Zhanjiang(lizhj8@ccmu.edu.cn) ; Zhou, Yuan(zhouyuan@psych.ac.cn)
英文摘要Background: Cognitive behavioural therapy (CBT) is considered an effective first-line treatment for obsessive-compulsive disorder (OCD). However, the neural basis of CBT for OCD has not yet been elucidated. The role of the amygdala in OCD and its functional coupling with the cerebral cortex have received increasing attention, and may provide new understanding of the neural basis of CBT for OCD. Methods: We acquired baseline resting-state functional MRI (fMRI) scans from 45 unmedicated patients with OCD and 40 healthy controls; we then acquired another wave of resting-state fMRI scans from the patients with OCD after 12 weeks of CBT. We performed seed-based resting-state functional connectivity analyses of the amygdala subregions to examine changes in patients with OCD as a result of CBT. Results: Compared to healthy controls, patients with OCD showed significantly increased resting-state functional connectivity at baseline between the left basolateral amygdala and the right middle frontal gyrus, and between the superficial amygdala and the right cuneus. In patients with OCD who responded to CBT, we found decreased resting-state functional connectivity after CBT between the amygdala subregions and the visual association cortices and increased resting-state functional connectivity between the amygdala subregions and the right inferior parietal lobe. Furthermore, these changes in resting-state functional connectivity were positively associated with changes in scores on the compulsion or obsession subscales of the Yale-Brown Obsessive-Compulsive Scale. Limitations: Because of the lack of a second scan for healthy controls after 12 weeks, our results may have been confounded by other variables. Conclusion: Our findings yield insights into the pathophysiology of OCD; they also reveal the potential neural changes elicited by CBT, and thus have implications for guiding effective treatment strategies with CBT for OCD.
收录类别SCI
WOS关键词BASOLATERAL AMYGDALA ; NEURAL PREDICTORS ; CORTEX ; PERSONALITY ; NETWORKS ; METAANALYSIS ; DIMENSIONS ; ACTIVATION ; MECHANISMS ; SCALE
资助项目National Natural Science Foundation of China[81271493] ; Beijing Natural Science Foundation[7122082] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[XMLX202129]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:000719546100001
出版者CMA-CANADIAN MEDICAL ASSOC
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
源URL[http://ir.psych.ac.cn/handle/311026/41233]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Li, Zhanjiang; Zhou, Yuan
作者单位1.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
5.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
6.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Jian,Yang, Xiangyun,Chen, Xiongying,et al. Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2021,46(6):E628-E638.
APA Gao, Jian.,Yang, Xiangyun.,Chen, Xiongying.,Liu, Rui.,Wang, Pengchong.,...&Zhou, Yuan.(2021).Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,46(6),E628-E638.
MLA Gao, Jian,et al."Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 46.6(2021):E628-E638.

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来源：心理研究所

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