中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院行为科学重点实验室
Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder

文献类型：期刊论文

作者Cui, Jian1,2; Wang, Yun1,2; Liu, Rui1,2; Chen, Xiongying1,2; Zhang, Zhifang1,2; Feng, Yuan1,2,3; Zhou, Jingjing1,2; Zhou, Yuan1,2,4,5; Wang, Gang1,2,3
刊名TRANSLATIONAL PSYCHIATRY
出版日期2021-12-13
卷号11期号:1页码:11
ISSN号2158-3188
DOI10.1038/s41398-021-01754-4
通讯作者Zhou, Yuan(zhouyuan@psych.ac.cn) ; Wang, Gang(gangwangdoc@ccmu.edu.cn)
英文摘要Antidepressants are often the first-line medications prescribed for patients with major depressive disorder (MDD). Given the critical role of the default mode network (DMN) in the physiopathology of MDD, the current study aimed to investigate the effects of antidepressants on the resting-state functional connectivity (rsFC) within and between the DMN subsystems. We collected restingstate functional magnetic resonance imaging (rs-fMRI) data from 36 unmedicated MDD patients at baseline and after escitalopram treatment for 12 weeks. The rs-fMRI data were also collected from 61 matched healthy controls at the time point with the same interval. Then, we decomposed the DMN into three subsystems based on a template from previous studies and computed the rsFC within and between the three subsystems. Finally, repeated measures analysis of covariance was conducted to identify the main effect of group and time and their interaction effect. We found that the significantly reduced within-subsystem rsFC in the DMN core subsystem in patients with MDD at baseline was increased after escitalopram treatment and became comparable with that in the healthy controls, whereas the reduced within-subsystem rsFC persisted in the DMN dorsal medial prefrontal cortex (dMPFC) and medial temporal subsystems in patients with MDD following escitalopram treatment. In addition, the reduced between-subsystem rsFC between the core and dMPFC subsystem showed a similar trend of change after treatment in patients with MDD. Moreover, our main results were confirmed using the DMN regions from another brain atlas. In the current study, we found different effects of escitalopram on the rsFC of the DMN subsystems. These findings deepened our understanding of the neuronal basis of antidepressants' effect on brain function in patients with MDD. The trial name: appropriate technology study of MDD diagnosis and treatment based on objective indicators and measurement. URL: http://www.chictr.org.cn/showproj.aspx?proj=21377.
收录类别SCI
WOS关键词PRESCRIPTION PATTERN ; TREATMENT RESPONSE ; CINGULATE CORTEX ; BRAIN ; MODULATION ; SCALE ; 1ST-EPISODE ; ADOLESCENTS ; MEMORY ; FMRI
资助项目National Key Research & Development Program of China[2016YFC1307200] ; National Natural Science Foundation of China[82071531] ; National Natural Science Foundation of China[81901372] ; National Natural Science Foundation of China[81901368] ; Capital's Funds for Health Improvement and Research[2020-4-2125] ; Scientific Research Common Program of Beijing Municipal Commission of Education[KM202010025010]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000729797000004
出版者SPRINGERNATURE
资助机构National Key Research & Development Program of China ; National Natural Science Foundation of China ; Capital's Funds for Health Improvement and Research ; Scientific Research Common Program of Beijing Municipal Commission of Education
源URL[http://ir.psych.ac.cn/handle/311026/41398]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Zhou, Yuan; Wang, Gang
作者单位1.Capital Med Univ, Beijing Key Lab Mental Disorders, Beijing Anding Hosp, Beijing 100088, Peoples R China
2.Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China
3.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100069, Peoples R China
4.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Jian,Wang, Yun,Liu, Rui,et al. Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder[J]. TRANSLATIONAL PSYCHIATRY,2021,11(1):11.
APA Cui, Jian.,Wang, Yun.,Liu, Rui.,Chen, Xiongying.,Zhang, Zhifang.,...&Wang, Gang.(2021).Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder.TRANSLATIONAL PSYCHIATRY,11(1),11.
MLA Cui, Jian,et al."Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder".TRANSLATIONAL PSYCHIATRY 11.1(2021):11.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。