A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma
文献类型：期刊论文
| 作者 | Wang, Cuicui1,2; Liu, Ming1; Cheng, Linyou1,2; Wei, Jianteng1,2; Wu, Ning1,2; Zheng, Lanhong1; Lin, Xiukun1,3 |
| 刊名 | EXPERIMENTAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 2012-04-01 |
| 卷号 | 237期号:4页码:442-450 |
| ISSN号 | 1535-3702 |
| 关键词 | Meretrix meretrix Linnaeus antitumor polypeptide non-small-cell lung carcinoma G(2)/M phase arrest apoptosis |
| 通讯作者 | Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China. |
| 英文摘要 | A novel polypeptide (Mere15) was purified from Meretrix meretrix Linnaeus by ammonium sulfate fractionation, ion exchange, gel filtration and reversed phase chromatography. Mere15 exhibited selective cytotoxicity to several human cancer cells. In vivo study showed that Mere15 significantly suppressed the growth of human lung adenocarcinoma A549 xenograft in nude mice. The mechanism was associated with a G(2)/M phase arrest followed by apoptosis, including membrane blebbing, loss of mitochondrial membrane potential, externalization of phosphatidylserine, chromosome condensation and DNA fragmentation. Western blot analysis showed that the intrinsic pathway was involved in Mere15-induced apoptosis. These results suggest that Mere15 may have therapeutic potential for the treatment of non-small-cell lung carcinoma. |
| 学科主题 | Medicine, Research & Experimental |
| 收录类别 | SCI |
| 原文出处 | 10.1258/ebm.2012.011337 |
| 语种 | 英语 |
| WOS记录号 | WOS:000304515100013 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12265]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Cuicui,Liu, Ming,Cheng, Linyou,et al. A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2012,237(4):442-450. |
| APA | Wang, Cuicui.,Liu, Ming.,Cheng, Linyou.,Wei, Jianteng.,Wu, Ning.,...&Lin, Xiukun.(2012).A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma.EXPERIMENTAL BIOLOGY AND MEDICINE,237(4),442-450. |
| MLA | Wang, Cuicui,et al."A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma".EXPERIMENTAL BIOLOGY AND MEDICINE 237.4(2012):442-450. |
入库方式： OAI收割
来源：海洋研究所
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