Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase
文献类型：期刊论文
| 作者 | Liu Ming1; Wei Jianteng1,2; Wang Hui1,2 ; Ding Lili1,2; Zhang Yuyan1; Lin Xiukun1,3
|
| 刊名 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2012-09-01 |
| 卷号 | 30期号:5页码:724-730 |
| 关键词 | Meretrix meretrix Linnaeus angiogenesis NOS nitric oxide (NO) |
| ISSN号 | 0254-4059 |
| 通讯作者 | Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 英文摘要 | Meretrix meretrix Linnaeus has long been used as traditional Chinese medicine in oriental medicine. The angiogentic activity of the extract of M. meretrix was investigated in this study, using human umbilical vein endothelial cells (HUVECs). Extract of M. meretrix Linnaeus (AFG-25) was prepared with acetone and ethanol precipitation, and further separated by Sephadex G-25 column. The results show that AFG-25 promoted proliferation, migration, and capillary-like tube formation in HUVECs, and in the presence of eNOS inhibitor NMA, the tube formation induced by AFG-25 is inhibited significantly. Moreover, AFG-25 could also promote the activation of endothelial nitric oxide synthase (eNOS) and the resultant elevation of nitric oxide (NO) production. The results suggested that M. meretrix contains active ingredients with angiogentic activity and eNOS/NO signal pathway is in part involved in the proangiogenesis effect induced by AFG-25. |
| 学科主题 | Limnology ; Oceanography |
| 收录类别 | SCI |
| 原文出处 | 10.1007/s00343-012-1241-5 |
| 语种 | 英语 |
| WOS记录号 | WOS:000308357800002 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12328]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Ming,Wei Jianteng,Wang Hui,et al. Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2012,30(5):724-730. |
| APA | Liu Ming,Wei Jianteng,Wang Hui,Ding Lili,Zhang Yuyan,&Lin Xiukun.(2012).Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,30(5),724-730. |
| MLA | Liu Ming,et al."Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 30.5(2012):724-730. |
入库方式： OAI收割
来源：海洋研究所
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