Genomic sequence-based discovery of novel angucyclinone antibiotics from marine Streptomyces sp W007
文献类型：期刊论文
| 作者 | Zhang, Hongyu1,4; Wang, Hongbo3; Wang, Yipeng1; Cui, Hongli1; Xie, Zeping1; Pu, Yang1; Pei, Shiqian3; Li, Fuchao2; Qin, Song1 |
| 刊名 | FEMS MICROBIOLOGY LETTERS
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 332期号:2页码:105-112 |
| 关键词 | genome sequence polyketide antifungal activity cytotoxicity angucyclinone antibiotics |
| ISSN号 | 0378-1097 |
| 通讯作者 | Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. |
| 英文摘要 | A large number of novel bioactive compounds were discovered from microbial secondary metabolites based on the traditional bioactivity screenings. Recent fermentation studies indicated that the crude extract of marine Streptomyces sp. W007 possessed great potential in agricultural fungal disease control against Phomopsis asparagi, Polystigma deformans, Cladosporium cucumerinum, Monilinia fructicola, and Colletotrichum lagenarium. To further evaluate the biosynthetic potential of secondary metabolites, we sequenced the genome of Streptomyces sp. W007 and analyzed the identifiable secondary metabolite gene clusters. Moreover, one gene cluster with type II PKS implied the possibility of Streptomyces sp. W007 to produce aromatic polyketide of angucyclinone antibiotics. Therefore, two novel compounds, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[a]anthracene and kiamycin with potent cytotoxicities against human cancer cell lines, were isolated from the culture broth of Streptomyces sp. W007. In addition, other four known angucyclinone antibiotics were obtained. The gene cluster for these angucyclinone antibiotics could be assigned to 20 genes. This work provides powerful evidence for the interplay between genomic analysis and traditional natural product isolation research. |
| 学科主题 | Microbiology |
| 收录类别 | SCI |
| 原文出处 | 10.1111/j.1574-6968.2012.02582.x |
| 语种 | 英语 |
| WOS记录号 | WOS:000305334300003 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12336]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Yantai Univ, Sch Pharm, Dept Pharmacol, Yantai, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hongyu,Wang, Hongbo,Wang, Yipeng,et al. Genomic sequence-based discovery of novel angucyclinone antibiotics from marine Streptomyces sp W007[J]. FEMS MICROBIOLOGY LETTERS,2012,332(2):105-112. |
| APA | Zhang, Hongyu.,Wang, Hongbo.,Wang, Yipeng.,Cui, Hongli.,Xie, Zeping.,...&Qin, Song.(2012).Genomic sequence-based discovery of novel angucyclinone antibiotics from marine Streptomyces sp W007.FEMS MICROBIOLOGY LETTERS,332(2),105-112. |
| MLA | Zhang, Hongyu,et al."Genomic sequence-based discovery of novel angucyclinone antibiotics from marine Streptomyces sp W007".FEMS MICROBIOLOGY LETTERS 332.2(2012):105-112. |
入库方式： OAI收割
来源：海洋研究所
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