Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity
文献类型：期刊论文
| 作者 | Li, Huili1,2,3 ; Sun, Boguang1,2; Jiang, Shuai1,2; Sun, Li1,2,3
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| 刊名 | BIOMOLECULES
 |
| 出版日期 | 2021-08-01 |
| 卷号 | 11期号:8页码:16 |
| 关键词 | cytokine Edwardsiella tarda infection antibody array immune response |
| DOI | 10.3390/biom11081242 |
| 通讯作者 | Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | Edwardsiella tarda is a Gram-negative bacterial pathogen with a broad range of hosts, including fish and mammals. In the present study, we used an advanced antibody array technology to identify the expression pattern of cytokines induced by E. tarda in a mouse infection model. In total, 31 and 24 differentially expressed cytokines (DECs) were identified in the plasma at 6 h and 24 h post-infection (hpi), respectively. The DECs were markedly enriched in the Gene Ontology (GO) terms associated with cell migration and response to chemokine and in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with immunity, diseases, and infection. Ten key DECs, including IL6 and TNF-alpha , were found to form extensive protein-protein interaction networks. IL6 was demonstrated to inhibit E. tarda infection and be required for E. tarda-induced inflammatory response. TNF-alpha also exerted an inhibitory effect on E. tarda infection, and knockdown of fish (Japanese flounder) TNF-alpha promoted E. tarda invasion in host cells. Together, the results of this study revealed a comprehensive profile of cytokines induced by E. tarda, thus adding new insights into the role of cytokine-associated immunity against bacterial infection and also providing the potential plasma biomarkers of E. tarda infection for future studies. |
| 资助项目 | grants of the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ0302-2] ; National Key R&D Program of China[2018YFD0900500] ; Youth Innovation Promotion Association CAS[2021204] ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000688909800001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/176233]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Li |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Expt Marine Biol, Inst Oceanol, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Huili,Sun, Boguang,Jiang, Shuai,et al. Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity[J]. BIOMOLECULES,2021,11(8):16. |
| APA | Li, Huili,Sun, Boguang,Jiang, Shuai,&Sun, Li.(2021).Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity.BIOMOLECULES,11(8),16. |
| MLA | Li, Huili,et al."Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity".BIOMOLECULES 11.8(2021):16. |
入库方式： OAI收割
来源：海洋研究所
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