Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512
文献类型：期刊论文
| 作者 | Chi, Lu-Ping1,2,3 ; Li, Xiao-Ming1,2; Wan, Yu-Peng1; Li, Yan-He1,2,3; Li, Xin1,2; Wang, Bin-Gui1,2,4
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2021-09-16 |
| 页码 | 6 |
| 关键词 | Aspergillus insuetus cold seep-derived fungus marine natural products antibacterial activity |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202100512 |
| 通讯作者 | Li, Xin(lixin@qdio.ac.cn) ; Wang, Bin-Gui(wangbg@nns.qdio.ac.cn) |
| 英文摘要 | Two new phenol derivatives, namely insphenol A (1) and acetylpeniciphenol (2), along with seven known analogs (3-9), were isolated from the deep-sea cold seep-derived fungus, Aspergillus insuetus SD-512. The structures of 1 and 2 were established by extensive interpretation of NMR and mass spectroscopic data. The absolute configuration of 1 was determined by the combination of coupling constant analysis and acid hydrolysis. Among the isolated compounds, insphenol A (1) represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. The isolated new compounds were evaluated for antibacterial activities against six human or aquatic pathogens, while compound 2 exhibited inhibitory effect against Edwardsiella tarda, Vibrio alginolyticus, and V. vulnificus, with MIC values of 4, 8, and 8 mu g/mL, respectively. |
| 资助项目 | National Key R&D Program of China[2018YFC0310800] ; National Natural Science Foundation of China[42076090] ; National Natural Science Foundation of China[U2006203] ; Shandong Provincial Natural Science Foundation[ZR2019ZD18] ; Basic Applied Research program of Qingdao[19-6-2-40-cg] ; Senior User Project of RV KEXUE[KEXUE2020GZ02] ; Center for Ocean Mega-Science, Chinese Academy of Sciences ; Taishan Scholar Project from Shandong Province[ts201511060] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000696224300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/176388]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Xin; Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chi, Lu-Ping,Li, Xiao-Ming,Wan, Yu-Peng,et al. Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512[J]. CHEMISTRY & BIODIVERSITY,2021:6. |
| APA | Chi, Lu-Ping,Li, Xiao-Ming,Wan, Yu-Peng,Li, Yan-He,Li, Xin,&Wang, Bin-Gui.(2021).Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512.CHEMISTRY & BIODIVERSITY,6. |
| MLA | Chi, Lu-Ping,et al."Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512".CHEMISTRY & BIODIVERSITY (2021):6. |
入库方式： OAI收割
来源：海洋研究所
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