Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression
文献类型：期刊论文
| 作者 | Liu, Chengzhang1; Yuan, Jianbo1,2; Zhang, Xiaojun1,2; Jin, Songjun1,2; Li, Fuhua1,2,3; Xiang, Jianhai1,2,3
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| 刊名 | GENOMICS
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| 出版日期 | 2021-11-01 |
| 卷号 | 113期号:6页码:3544-3555 |
| 关键词 | microRNA miRNA cluster Sea cucumber Aestivation Regeneration |
| ISSN号 | 0888-7543 |
| DOI | 10.1016/j.ygeno.2021.08.003 |
| 通讯作者 | Zhang, Xiaojun(xjzhang@qdio.ac.cn) ; Xiang, Jianhai(jhxiang@qdio.ac.cn) |
| 英文摘要 | Echinoderms are marine deuterostomes with fascinating adaptation features such as aestivation and organ regeneration. However, post-transcriptional gene regulation by microRNAs (miRNAs) underlying these features are largely unexplored. Here, using homology-based and de novo approaches supported by expression data, we provided a comprehensive annotation of miRNA genes in the sea cucumber Apostichopus japonicus. By linkage and phylogenic analyses, we characterized miRNA genomic organization, evolutionary history and expression regulation. The results showed that sea cucumbers evolved a large number of new miRNAs, which tended to form polycistronic clusters via tandem duplication that had been especially active in the echinoderms. Most new miRNAs were weakly expressed, but miRNA clustering increased the expression level of clustered new miRNAs. The most abundantly expressed new miRNAs were organized in a single tandem cluster (cluster n2), which was activated during aestivation and intestine regeneration. Overall, our analyses suggest that clustering of miRNAs is important for their evolutionary origin, expression control, and functional cooperation. |
| 资助项目 | Ocean Science Data Center, Institute of Oceanology, CAS ; National Natural Science Foundation of China[31772885] ; National Key R&D Program of China[2018YFD0900103] ; Senior User Project of RV KEXUE[KEXUE2018G19] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000703997800002 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/176494]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhang, Xiaojun; Xiang, Jianhai |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Chengzhang,Yuan, Jianbo,Zhang, Xiaojun,et al. Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression[J]. GENOMICS,2021,113(6):3544-3555. |
| APA | Liu, Chengzhang,Yuan, Jianbo,Zhang, Xiaojun,Jin, Songjun,Li, Fuhua,&Xiang, Jianhai.(2021).Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression.GENOMICS,113(6),3544-3555. |
| MLA | Liu, Chengzhang,et al."Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression".GENOMICS 113.6(2021):3544-3555. |
入库方式： OAI收割
来源：海洋研究所
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