Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities
文献类型：期刊论文
| 作者 | Yang, Haoyue1,2,3 ; Xing, Ronge1,2,3; Liu, Song1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
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| 刊名 | BIOENGINEERED
 |
| 出版日期 | 2021 |
| 卷号 | 12期号:1页码:7235-7247 |
| 关键词 | Apoptosis cadmium chloride fucoxanthin oxidative stress renal function |
| ISSN号 | 2165-5979 |
| DOI | 10.1080/21655979.2021.1973875 |
| 通讯作者 | Xing, Ronge(rongexing1006@126.com) |
| 英文摘要 | Kidney damages caused by cadmium are considered to be one of the most dangerous consequences for the human body. This study aimed to investigate the protective effects of fucoxanthin supplementation on mice models subjected to cadmium-induced kidney damage. The mice treated with cadmium chloride (CdCl2) were observed to have significantly reduced the cross-section area of glomeruli. Cadmium exposure has also caused the damage of the structural integrity of mitochondria and increased blood urea nitrogen (BUN), kidney injury molecule 1 (KIM1), and neutrophil gelatinase associated lipocalin (NGAL) levels. Peroxidase (POD), superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) levels in cadmium-exposed mice were markedly declined. Caspase3, caspase8, and caspase9 gene expressions in association with apoptosis were dramatically elevated in renal tissues. The CdCl2 treated mice were orally administered with 50 mg/kg Shenfukang, 10 mg/kg, 25 mg/kg, and 50 mg/kg fucoxanthin for 14 days. The results revealed that high doses of fucoxanthin administration significantly decreased BUN, KIM1, NGAL levels, increasing POD, SOD, CAT, and ascorbate APX levels. Fucoxanthin administration also promoted recovery of the renal functions, micro-structural organization, and ultra-structural organization in the renal cells. In summary, the ameliorative effects of fucoxanthin supplementation against cadmium-induced kidney damage were mediated via inhibiting oxidative stress and apoptosis, promoting the recovery of structural integrity of mitochondria. |
| 资助项目 | National Key R&D Program of China[2018YFC0311305] ; National Key R&D Program of China[2019YFD0900705] ; Key Research and Development Program of Shandong Province[2019GHY112015] ; Key Research and Development Program of Shandong Province[2019YYSP028] |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000702609800001 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/176541]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xing, Ronge |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Haoyue,Xing, Ronge,Liu, Song,et al. Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities[J]. BIOENGINEERED,2021,12(1):7235-7247. |
| APA | Yang, Haoyue,Xing, Ronge,Liu, Song,Yu, Huahua,&Li, Pengcheng.(2021).Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities.BIOENGINEERED,12(1),7235-7247. |
| MLA | Yang, Haoyue,et al."Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities".BIOENGINEERED 12.1(2021):7235-7247. |
入库方式： OAI收割
来源：海洋研究所
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