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Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition

文献类型：期刊论文

作者Wu, Ning1,3,5; Li, Zhi1,2,4; Wang, Jing1,2; Geng, Lihua1,2; Yue, Yang1,2; Deng, Zhenzhen1,2,4; Wang, Qingchi1,2,4; Zhang, Quanbin1,2,4
刊名CARBOHYDRATE POLYMERS
出版日期2021-12-01
卷号273页码:10
关键词Fucoidans COVID-19 Pulmonary fibrosis Epithelial-mesenchymal transition TGF-beta PI3K/AKT pathway
ISSN号0144-8617
DOI10.1016/j.carbpol.2021.118567
通讯作者Wu, Ning(wuning@qdio.ac.cn) ; Zhang, Quanbin(qbzhang@qdio.ac.cn)
英文摘要Diffuse alveolar injury and pulmonary fibrosis (PF) are the main causes of death of Covid-19 cases. In this study a low molecular weight fucoidan (LMWF) with unique structural was obtained from Laminaria japonica, and its antiPF and anti-epithelial-mesenchymal transition (EMT) bioactivity were investigated both in vivo and in vitro. After LWMF treatment the fibrosis and inflammatory factors stimulated by Bleomycin (BLM) were in lung tissue. Immunohistochemical and Western-blot results found the expression of COL2A1, beta-catenin, TGF-beta, TNF-alpha and IL-6 were declined in mice lung tissue. Besides, the phosphorylation of PI3K and Akt were inhibited by LMWF. In addition, the progression of EMT induced by TGF-beta 1 was inhibited by LMWF through down-regulated both TGF-beta/Smad and PI3K/AKT signaling pathways. These data indicate that unique LMWF can protect the lung from fibrosis by weakening the process of inflammation and EMT, and it is a promising therapeutic option for the treatment of PF.
资助项目National Key Research and Development Program of China[2019YFD0900705] ; Nantong Science and Technology program[MS12021037] ; Special Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology[OF2020NO02]
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000704364500005
出版者ELSEVIER SCI LTD
源URL[http://ir.qdio.ac.cn/handle/337002/176618]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wu, Ning; Zhang, Quanbin
作者单位1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Nantong Zhongke Marine Sci & Technol Res & Dev Ct, Nantong, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Ning,Li, Zhi,Wang, Jing,et al. Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition[J]. CARBOHYDRATE POLYMERS,2021,273:10.
APA Wu, Ning.,Li, Zhi.,Wang, Jing.,Geng, Lihua.,Yue, Yang.,...&Zhang, Quanbin.(2021).Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition.CARBOHYDRATE POLYMERS,273,10.
MLA Wu, Ning,et al."Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition".CARBOHYDRATE POLYMERS 273(2021):10.

入库方式： OAI收割

来源：海洋研究所

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