中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069

文献类型:期刊论文

作者Song, Fuhang1; Yang, Na2,3; Khalil, Zeinab G.4; Salim, Angela A.4; Han, Jiahui5; Bernhardt, Paul, V6; Lin, Rui5; Xu, Xiuli5; Capon, Robert J.4
刊名CHEMISTRY & BIODIVERSITY
出版日期2021-10-27
页码7
ISSN号1612-1872
关键词marine-derived actinomycete bhimamycin J SARS-CoV-2 molecular docking angiotensin converting enzyme2
DOI10.1002/cbdv.202100674
通讯作者Xu, Xiuli(xuxl@cugb.edu.cn) ; Capon, Robert J.(r.capon@uq.edu.au)
英文摘要Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J (1). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7 % at 25 mu g/mL.
资助项目National Key R&D Program of China[2018YFC0311000] ; Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA[MBSMAT-2019-06] ; National Natural Science Foundation of China[81973204] ; Research Foundation for Advanced Talents of Beijing Technology and Business University[19008020158]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000711551900001
源URL[http://ir.qdio.ac.cn/handle/337002/176749]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Xu, Xiuli; Capon, Robert J.
作者单位1.Beijing Technol & Business Univ, Sch Light Ind, Beijing 100048, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
4.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
5.China Univ Geosci, Sch Ocean Sci, Beijing 100083, Peoples R China
6.Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia
推荐引用方式
GB/T 7714
Song, Fuhang,Yang, Na,Khalil, Zeinab G.,et al. Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069[J]. CHEMISTRY & BIODIVERSITY,2021:7.
APA Song, Fuhang.,Yang, Na.,Khalil, Zeinab G..,Salim, Angela A..,Han, Jiahui.,...&Capon, Robert J..(2021).Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069.CHEMISTRY & BIODIVERSITY,7.
MLA Song, Fuhang,et al."Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069".CHEMISTRY & BIODIVERSITY (2021):7.

入库方式: OAI收割

来源:海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。