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Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J

文献类型：期刊论文

作者Sun, Yuhao1,2,3; Chen, Xiaolin1,2,3; Liu, Hong1,2,3; Liu, Song1,2,3; Yu, Huahua1,2,3; Wang, Xueqin1,2,3; Qin, Yukun1,2,3; Li, Pengcheng1,2,3
刊名MOLECULES
出版日期2021-06-01
卷号26期号:11页码:15
关键词Sargassum fusiforme polysaccharide long-chain alkyl group antiviral activity ALV-J
DOI10.3390/molecules26113265
通讯作者Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要Avian leukosis virus subgroup J (ALV-J) is an immunosuppressive virus which has caused heavy losses to the poultry breeding industry. Currently, there is no effective medicine to treat this virus. In our previous experiments, the low-molecular-weight Sargassum fusiforme polysaccharide (SFP) was proven to possess antiviral activity against ALV-J, but its function was limited to the virus adsorption stage. In order to improve the antiviral activity of the SFP, in this study, three new SFP long-chain alkyl group nanomicelles (SFP-C12M, SFP-C14M and SFP-C16M) were prepared. The nanomicelles were characterized according to their physical and chemical properties. The nanomicelles were characterized by particle size, zeta potential, polydispersity index, critical micelle concentration and morphology. The results showed the particle sizes of the three nanomicelles were all approximately 200 nm and SFP-C14M and SFP-C16M were more stable than SFP-C12M. The newly prepared nanomicelles exhibited a better anti-ALV-J activity than the SFP, with SFP-C16M exhibiting the best antiviral effects in both the virus adsorption stage and the replication stage. The results of the giant unilamellar vesicle exposure experiment demonstrated that the new virucidal effect of the nanomicelles might be caused by damage to the phospholipid membrane of ALV-J. This study provides a potential idea for ALV-J prevention and development of other antiviral drugs.
资助项目National Key R&D Program of China[2018YFD0901104] ; Shandong Province Key Research and Development Project[2018GHY115008] ; Shandong Province Key Research and Development Project[2017GHY215008] ; Qingdao Science and Technology Project[17-3-3-60-nsh]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000660362800001
出版者MDPI
源URL[http://ir.qdio.ac.cn/handle/337002/176831]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Li, Pengcheng
作者单位1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Yuhao,Chen, Xiaolin,Liu, Hong,et al. Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J[J]. MOLECULES,2021,26(11):15.
APA Sun, Yuhao.,Chen, Xiaolin.,Liu, Hong.,Liu, Song.,Yu, Huahua.,...&Li, Pengcheng.(2021).Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J.MOLECULES,26(11),15.
MLA Sun, Yuhao,et al."Preparation of New Sargassum fusiforme Polysaccharide Long-Chain Alkyl Group Nanomicelles and Their Antiviral Properties against ALV-J".MOLECULES 26.11(2021):15.

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来源：海洋研究所

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