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Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa

文献类型：期刊论文

作者He, Xin1,2,3,4,7; Wu, Fucun1,2,3,6,7; Zhang, Linlin1,2,3,6; Li, Li1,2,5,6; Zhang, Guofan1,2,3,6
刊名SCIENTIFIC REPORTS
出版日期2021-05-31
卷号11期号:1页码:12
ISSN号2045-2322
DOI10.1038/s41598-021-90800-8
通讯作者Wu, Fucun(wufucun@qdio.ac.cn) ; Zhang, Linlin(linlinzhang@qdio.ac.cn)
英文摘要Lophotrochozoan species exhibit wide morphological diversity; however, the molecular basis underlying this diversity remains unclear. Here, we explored the evolution of Notch pathway genes across 37 metazoan species via phylogenetic and molecular evolutionary studies with emphasis on the lophotrochozoans. We displayed the components of Notch pathway in metazoans and found that Delta and Hes/Hey-related genes, as well as their functional domains, are duplicated in lophotrochozoans. Comparative transcriptomics analyses allow us to pinpoint sequence divergence of multigene families in the Notch signalling pathway. We identified the duplication mechanism of a mollusc-specific gene, Delta2, and found it displayed complementary expression throughout development. Furthermore, we found the functional diversification not only in expanded genes in the Notch pathway (Delta and Hes/Hey-related genes), but also in evolutionary conservative genes (Notch, Presenilin, and Su(H)). Together, this comprehensive study demonstrates conservation and divergence within the Notch pathway, reveals evolutionary relationships among metazoans, and provides evidence for the occurrence of developmental diversity in lophotrochozoans, as well as a basis for future gene function studies.
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24030105] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB42000000] ; Pilot National Laboratory for Marine Science and Technology[YJ2019NO01] ; Key Development Project of Centre for Ocean Mega-Research of Science, Chinese academy of science[COMS2019R01] ; National Natural Science Foundation of China[41976088] ; National Science Foundation of China[31972790] ; China Agriculture Research System of MOF and MARA
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000659203100008
出版者NATURE RESEARCH
源URL[http://ir.qdio.ac.cn/handle/337002/176909]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wu, Fucun; Zhang, Linlin
作者单位1.Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Ctr Ocean Megasci, Inst Oceanol, Qingdao 266071, Peoples R China
3.Lab Marine Biol & Biotechnol, Pilot Natl Lab Marine Sci & Technol, Qingdao 266237, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
5.Pilot Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
6.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China
7.Chinese Acad Sci, Innovat Seed Design, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 He, Xin,Wu, Fucun,Zhang, Linlin,et al. Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa[J]. SCIENTIFIC REPORTS,2021,11(1):12.
APA He, Xin,Wu, Fucun,Zhang, Linlin,Li, Li,&Zhang, Guofan.(2021).Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa.SCIENTIFIC REPORTS,11(1),12.
MLA He, Xin,et al."Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa".SCIENTIFIC REPORTS 11.1(2021):12.

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来源：海洋研究所

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