Identification and characterization of immune-related lncRNAs and lncRNA-miRNA-mRNA networks of Paralichthys olivaceus involved in Vibrio anguillarum infection
文献类型：期刊论文
| 作者 | Ning, Xianhui1,2,3,4; Sun, Li1,3 |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2021-06-15 |
| 卷号 | 22期号:1页码:13 |
| 关键词 | LncRNA Paralichthys olivaceus Vibrio anguillarum Immune pathway ceRNA network |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/s12864-021-07780-2 |
| 通讯作者 | Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | Background Long non-coding RNAs (lncRNAs) structurally resemble mRNAs and exert crucial effects on host immune defense against pathogen infection. Japanese flounder (Paralichthys olivaceus) is an economically important marine fish susceptible to Vibrio anguillarum infection. To date, study on lncRNAs in flounder is scarce. Results Here, we reported the first systematic identification and characterization of flounder lncRNAs induced by V. anguillarum infection at different time points. A total of 2,368 lncRNAs were identified, 414 of which were differentially expressed lncRNAs (DElncRNAs) that responded significantly to V. anguillarum infection. For these DElncRNAs, 3,990 target genes (named DETGs) and 42 target miRNAs (named DETmiRs) were identified based on integrated analyses of lncRNA-mRNA and lncRNA-miRNA expressions, respectively. The DETGs were enriched in a cohort of functional pathways associated with immunity. In addition to modulating mRNAs, 36 DElncRNAs were also found to act as competitive endogenous RNAs (ceRNAs) that regulate 37 DETGs through 16 DETmiRs. The DETmiRs, DElncRNAs, and DETGs formed ceRNA regulatory networks consisting of 114 interacting DElncRNAs-DETmiRs-DETGs trinities spanning 10 immune pathways. Conclusions This study provides a comprehensive picture of lncRNAs involved in V. anguillarum infection. The identified lncRNAs and ceRNA networks add new insights into the anti-bacterial immunity of flounder. |
| 资助项目 | National Natural Science Foundation of China[31730100] ; National Natural Science Foundation of China[42006082] ; China Postdoctoral Science Foundation[2019M662456] ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000664816400001 |
| 出版者 | BMC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/177011]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Nanjing Normal Univ, Coll Marine Sci & Engn, Nanjing 210023, Jiangsu, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Coinnovat Ctr Marine Bioind Technol Jiangsu Prov, Lianyungang 222005, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ning, Xianhui,Sun, Li. Identification and characterization of immune-related lncRNAs and lncRNA-miRNA-mRNA networks of Paralichthys olivaceus involved in Vibrio anguillarum infection[J]. BMC GENOMICS,2021,22(1):13. |
| APA | Ning, Xianhui,&Sun, Li.(2021).Identification and characterization of immune-related lncRNAs and lncRNA-miRNA-mRNA networks of Paralichthys olivaceus involved in Vibrio anguillarum infection.BMC GENOMICS,22(1),13. |
| MLA | Ning, Xianhui,et al."Identification and characterization of immune-related lncRNAs and lncRNA-miRNA-mRNA networks of Paralichthys olivaceus involved in Vibrio anguillarum infection".BMC GENOMICS 22.1(2021):13. |
入库方式： OAI收割
来源：海洋研究所
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