The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas
文献类型：期刊论文
| 作者 | Xin, Lusheng1,2 ; Liu, Chang3,4,5; Zhang, Huan1; Qiu, Limei1; Wang, Lingling2,3,4,5; Song, Linsheng2,3,4,5
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| 刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 出版日期 | 2021-10-01 |
| 卷号 | 123页码:8 |
| 关键词 | Crassostrea gigas Cytokine IL-12 IL-12 p35 subunit |
| ISSN号 | 0145-305X |
| DOI | 10.1016/j.dci.2021.104145 |
| 通讯作者 | Song, Linsheng(lshsong@dlou.edu.cn) |
| 英文摘要 | Vertebrate interleukin-12 (IL-12) is a heterodimeric cytokine composing of two subunits (p35 and p40). In the present study, a p35-like subunit homolog of vertebrate IL-12 was identified from oyster Crassostrea gigas (designated as CgIL12p35L), with an open reading frame of 411 bp encoding a putative peptide of 136 amino acids. There was a long four-helix chain in CgIL12p35L, which was similar as that in vertebrate IL-12 p35. Comparative genomic analysis showed that there were conservative kinds of syntenic genes flanked CgIL12p35L. The mRNA transcripts of CgIL12p35L were constitutively expressed in various tissues and its mRNA expression level in haemocytes increased significantly after bacteria challenge. The activity of haemolymph to eliminate bacteria from the oysters treated with recombinant CgIL12p35L protein (rCgIL12p35L) in vivo increased significantly. The results collectively indicated that the homolog of vertebrate IL-12 p35 subunit existed in oysters, and it was involved in immune defense against bacteria challenge. |
| 资助项目 | National Science Foundation of China[U1706204] ; National Key RD Program[2018YFD0900504] ; China Agriculture Research System of MOF and MARA ; Outstanding Talents and Innovative teams of Agricultural Scientific Research in Ministry of Agriculture ; Research Foundation for Distinguished Professor in Liaoning[XLYC1902012] ; Research Foundation for Climbing Scholars in Liaoning and Talented Scholars in Dalian Ocean University |
| WOS研究方向 | Fisheries ; Immunology ; Veterinary Sciences ; Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:000672560600004 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/177026]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Song, Linsheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266235, Peoples R China 3.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol, Dalian 116023, Peoples R China 4.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, Dalian 116023, Peoples R China 5.Dalian Ocean Univ, Dalian Key Lab Aquat Anim Dis Prevent & Control, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xin, Lusheng,Liu, Chang,Zhang, Huan,et al. The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2021,123:8. |
| APA | Xin, Lusheng,Liu, Chang,Zhang, Huan,Qiu, Limei,Wang, Lingling,&Song, Linsheng.(2021).The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,123,8. |
| MLA | Xin, Lusheng,et al."The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 123(2021):8. |
入库方式： OAI收割
来源：海洋研究所
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