CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense
文献类型：期刊论文
| 作者 | Li, Xue-peng1 ; Chen, Guan-yu1; Jin, Qiu1; Lou, Fang-rui1; Liu, Bing-jian3; Zhang, Jian1; Feng, Ji-xing1; Chen, Tian-tian2
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2021-12-01 |
| 卷号 | 192页码:1021-1028 |
| ISSN号 | 0141-8130 |
| 关键词 | Interleukin-11 Cynoglossus semilaevis Peripheral blood leukocytes Phagocytosis Antibacterial immunity |
| DOI | 10.1016/j.ijbiomac.2021.10.080 |
| 通讯作者 | Li, Xue-peng(lixuepeng14@mails.ucas.ac.cn) ; Chen, Tian-tian(chentian0819@163.com) |
| 英文摘要 | Interleukin (IL)-11 is a multifunctional cytokine belonging to the IL-6 family, which plays essential roles in immune response. However, much less is known about the immunological functions of IL-11 in teleost. In this study, we investigated the immune properties of a teleost IL-11 homologue (CsIL-11) from tongue sole Cynoglossus semilaevis. CsIL-11 possesses four conserved alpha-helices and conserved CsIL-11 receptor binding residues L86 and R187, and shares 23.3%-80.1% identities with other IL-11 homologues. CsIL-11 expression was constitutive in tissues, with most abundant in blood and least abundant in spleen, and upregulated by bacterial challenge in blood, spleen, and head kidney. Recombinant CsIL-11 (rCsIL-11) in the native form of monomer, could bind to peripheral blood leukocytes (PBLs) membrane and enhance the activation and phagocytosis of PBLs. When administered in vivo, rCsIL-11 could markedly promote the host to defend against microbial infection. Overall, our findings show that CsIL-11 plays a pivotal role in regulating PBLs phagocytosis and antibacterial immunity. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000710454100007 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/176731]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Li, Xue-peng; Chen, Tian-tian |
| 作者单位 | 1.Yantai Univ, Sch Ocean, Yantai, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 3.Zhejiang Ocean Univ, Marine Sci & Technol Coll, Zhoushan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xue-peng,Chen, Guan-yu,Jin, Qiu,et al. CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,192:1021-1028. |
| APA | Li, Xue-peng.,Chen, Guan-yu.,Jin, Qiu.,Lou, Fang-rui.,Liu, Bing-jian.,...&Chen, Tian-tian.(2021).CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,192,1021-1028. |
| MLA | Li, Xue-peng,et al."CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 192(2021):1021-1028. |
入库方式： OAI收割
来源：海洋研究所
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