Triterpenoid saponin biosynthesis genes and their expression patterns during the development of sea cucumber Apostichopus japonicus
文献类型：期刊论文
| 作者 | Yang, Yujia1; Li, Xiaoni2; Sun, Lina2 |
| 刊名 | JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2021-06-14 |
| 页码 | 14 |
| 关键词 | triterpene saponin biosynthesis sea cucumber enzyme expression development |
| ISSN号 | 2096-5508 |
| DOI | 10.1007/s00343-020-0209-0 |
| 通讯作者 | Sun, Lina(sunlina@qdio.ac.cn) |
| 英文摘要 | Sea cucumbers are echinoderm species with a leathery skin and an elongated body. Natural compounds, including saponins, have been previously isolated from sea cucumber. The majority of saponins derived from this organism typically belong to the triterpene glycosides, which exhibit various biological effects (e.g., antifungal, cytotoxic, hemolytic, and cytostatic immunomodulatory activities). In the present study, 30 saponin biosynthesis enzymes, namely 2 AACTs, 2 FPSs, 2 HMGSs, 2 OSCs, 1 SS, 2 SEs, and 19 UGTs, were found in the genome of sea cucumber Apostichopus japonicus. Compared with upstream saponin biosynthesis enzymes (i.e., AACTs, FPSs, HMGSs, OSCs, and SSs), the downstream saponin biosynthesis enzymes (SEs and UGTs) shared lower amino acid sequence similarity with the corresponding genes in other echinoderms. It was proposed that the enzyme structures comprised both alpha-helices and beta-sheets. Notably, only a low percentage of beta-sheets were present in FPSs, OSCs, and SS. The saponin biosynthesis enzymes showed dynamic expression patterns during five critical developmental stages of A. japonicus (fertilized oocytes, blastula, gastrula, doliolaria, and penractula). The present study involved elucidation of putative saponin biosynthesis pathways in sea cucumber and provides a valuable platform for further investigation of saponin biosynthesis in echinoderms. |
| 资助项目 | National Key R&D Program of China[2018YFD0900105] ; Agricultural Seed Project of Shandong Province[2017LZGC010] ; Youth Innovation Promotion Association CAS[2019209] |
| WOS研究方向 | Marine & Freshwater Biology ; Oceanography |
| 语种 | 英语 |
| WOS记录号 | WOS:000661406900001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/176879]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Sun, Lina |
| 作者单位 | 1.Ocean Univ China, Inst Evolut & Marine Biodivers, Lab Evolut & Dev, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yujia,Li, Xiaoni,Sun, Lina. Triterpenoid saponin biosynthesis genes and their expression patterns during the development of sea cucumber Apostichopus japonicus[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2021:14. |
| APA | Yang, Yujia,Li, Xiaoni,&Sun, Lina.(2021).Triterpenoid saponin biosynthesis genes and their expression patterns during the development of sea cucumber Apostichopus japonicus.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,14. |
| MLA | Yang, Yujia,et al."Triterpenoid saponin biosynthesis genes and their expression patterns during the development of sea cucumber Apostichopus japonicus".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2021):14. |
入库方式： OAI收割
来源：海洋研究所
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