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RNA-Seq analysis and WGCNA reveal dynamic molecular responses to air exposure in the hard clam Mercenaria mercenaria

文献类型：期刊论文

作者Zhou, Cong1,2,4,5,6; Song, Hao1,2,3,4,6; Feng, Jie1,2,4,6; Hu, Zhi1,2,4,5,6; Yu, Zheng-Lin1,2,4,5,6; Yang, Mei-Jie1,2,4,5,6; Shi, Pu1,2,4,5,6; Li, Yong-Ren7; Guo, Yong-Jun7; Zhang, Tao1,2,3,4,6
刊名GENOMICS
出版日期2021-07-01
卷号113期号:4页码:2847-2859
关键词Air exposure Mercenaria mercenaria Response Transcriptome
ISSN号0888-7543
DOI10.1016/j.ygeno.2021.06.025
通讯作者Zhang, Tao(tzhang@qdio.ac.cn)
英文摘要Intertidal bivalves are constantly exposed to air due to daily and seasonal tidal cycles. The hard clam Mercenaria mercenaria is an economically important bivalve species and often subjected to air exposure for more than 10 days during long-distance transportation. Hard clam exhibits remarkable tolerance to air exposure. In this study, we performed RNA sequencing on hemocytes of M. mercenaria exposed to air for 0, 1, 5, 10, 20 and 30 days. The overall and dynamic molecular responses of hard clams to air exposure were revealed by different transcriptomic analysis strategies. As a result, most cytochrome P450 1A and 3A, and monocarboxylate transporter family members were up-regulated during air exposure. Additionally, the dominant molecular process in response to 5-d, 10-d, 20-d and 30-d air exposure was refolding of misfolded proteins in endoplasmic reticulum, lysosome-mediated degradation of phospholipids, protein metabolism and reorganization of cytoskeleton, and activation of anti-apoptotic process, respectively. Our results facilitated comprehensive understanding of the tolerance mechanisms of intertidal bivalves to air exposure.
资助项目earmarked fund for the Modern Agro-industry Technology Research System[CARS-49] ; Major Applied Technology Innovation Project in Agriculture of Shandong Province[SF1405303301] ; Industry Leading Talents Project of Taishan Scholars[LJNY201704] ; 'Double Hundred' Blue Industry Leader Team of Yantai ; Creative Team Project of the Laboratory for Marine Ecology and Environmental Science, Qingdao Pilot National Laboratory for Marine Science and Technology[LMEESCTSP-2018-1] ; Science and Technology Project of Tianjin
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity
语种英语
WOS记录号WOS:000669212300003
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://ir.qdio.ac.cn/handle/337002/177008]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Zhang, Tao
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
7.Tianjin Agr Univ, Fisheries Coll, Tianjin Key Lab Aqua Ecol & Aquaculture, Tianjin 300384, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Cong,Song, Hao,Feng, Jie,et al. RNA-Seq analysis and WGCNA reveal dynamic molecular responses to air exposure in the hard clam Mercenaria mercenaria[J]. GENOMICS,2021,113(4):2847-2859.
APA Zhou, Cong.,Song, Hao.,Feng, Jie.,Hu, Zhi.,Yu, Zheng-Lin.,...&Zhang, Tao.(2021).RNA-Seq analysis and WGCNA reveal dynamic molecular responses to air exposure in the hard clam Mercenaria mercenaria.GENOMICS,113(4),2847-2859.
MLA Zhou, Cong,et al."RNA-Seq analysis and WGCNA reveal dynamic molecular responses to air exposure in the hard clam Mercenaria mercenaria".GENOMICS 113.4(2021):2847-2859.

入库方式： OAI收割

来源：海洋研究所

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