Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro
文献类型：期刊论文
| 作者 | Liu, Ming1; Zhang, Wei2; Wei, Jianteng1; Qiu, Lin3; Lin, Xiukun1 |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2012-06-01 |
| 卷号 | 211期号:2页码:126-134 |
| 关键词 | Bis(2 Apoptosis Topoisomerase I inhibition Minor groove binding 3-dibromo-4 5-dihydroxybenzyl) ether |
| ISSN号 | 0378-4274 |
| 通讯作者 | Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China. |
| 英文摘要 | Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a marine bromophenol compound derived from marine algae. Previous reports have shown that BDDE possesses cytotoxic activity. However, the mechanisms of its apoptotic activity as well as its potential cellular targets remain unclear. The present study demonstrated that BDDE displays broad-spectrum in vitro anticancer capabilities and exhibits potent apoptotic activity in K562 cells via mitochondrial pathway. Further study revealed that BDDE inhibits the activity of topoisomerase I but does not stimulate the formation of topoisomerase I-DNA complex nor intercalate into DNA. Ethidium bromide displacement fluorescence assay and molecular modeling results showed that BDDE mainly targets DNA and binds to DNA minor groove, and thereafter inhibits the activity of topoisomerase I. The results of this study indicated that BDDE, which has unique chemical structure different from current topoisomerase I inhibitors, could serve as a lead template for rational drug design and for future anticancer agents development. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Toxicology |
| 收录类别 | SCI |
| 原文出处 | 10.1016/j.toxlet.2012.03.771 |
| 语种 | 英语 |
| WOS记录号 | WOS:000304744700006 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12359]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.So Res Inst, Birmingham, AL 35205 USA 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ming,Zhang, Wei,Wei, Jianteng,et al. Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro[J]. TOXICOLOGY LETTERS,2012,211(2):126-134. |
| APA | Liu, Ming,Zhang, Wei,Wei, Jianteng,Qiu, Lin,&Lin, Xiukun.(2012).Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro.TOXICOLOGY LETTERS,211(2),126-134. |
| MLA | Liu, Ming,et al."Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro".TOXICOLOGY LETTERS 211.2(2012):126-134. |
入库方式： OAI收割
来源：海洋研究所
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