microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation
文献类型：期刊论文
| 作者 | Chen, Hao1,2,3,4 ; Wang, Minxiao1,2,3,4; Zhang, Huan1,2,3,4; Wang, Hao1,2,3,4; Zhou, Li1,2,3,4; Zhong, Zhaoshan1,2,3,4,5; Cao, Lei1,2,3,4; Lian, Chao1,2,3,4; Sun, Yan1,2,3,4; Li, Chaolun1,2,3,4,5
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| 刊名 | FISH & SHELLFISH IMMUNOLOGY
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| 出版日期 | 2021-12-01 |
| 卷号 | 119页码:420-431 |
| 关键词 | Bathymodiolinae mussel Pattern recognition receptor Methane oxidation bacteria Chemosynthetic ecosystem miRNAs Symbiosis |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2021.10.025 |
| 通讯作者 | Li, Chaolun(lcl@qdio.ac.cn) |
| 英文摘要 | Bathymodiolinae mussels are dominant species in cold seeps and hydrothermal vents and could harbor endosymbionts in gill bacteriocytes. However, mechanisms underlying the symbiosis have remained largely undisclosed for years. In the present study, the global expression pattern of immune-related genes and miRNAs were surveyed in Gigantidas platifrons during bacterial challenges using enriched symbiotic methane oxidation bacteria MOBs or nonsymbiotic Vibrio. As a result, multiple pattern recognition receptors were found differentially expressed at 12 h and 24 h post bacteria challenges and distinctly clustered between stimulations. Dozens of immune effectors along with signal transducers were also modulated simultaneously during MOB or Vibrio challenge. A total of 459 miRNAs were identified in the gill while some were differentially expressed post MOB or nonsymbiotic bacteria challenge. A variety of immune-related genes were annotated as target genes of aforesaid differentially expressed miRNAs. As a result, biological processes including the immune recognition, lysosome activity and bacteria engulfment were suggested to be dynamically modulated by miRNAs in either symbiotic or nonsymbiotic bacteria challenge. It was suggested that G. platifrons mussels could maintain a robust immune response against invading pathogens while establishing symbiosis with chemosynthetic bacteria with the orchestra of immune-related genes and miRNAs. |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000714697000006 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/177287]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Li, Chaolun |
| 作者单位 | 1.Chinese Acad Sci, Ctr Deep Sea Res, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing 10049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Hao,Wang, Minxiao,Zhang, Huan,et al. microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation[J]. FISH & SHELLFISH IMMUNOLOGY,2021,119:420-431. |
| APA | Chen, Hao.,Wang, Minxiao.,Zhang, Huan.,Wang, Hao.,Zhou, Li.,...&Li, Chaolun.(2021).microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation.FISH & SHELLFISH IMMUNOLOGY,119,420-431. |
| MLA | Chen, Hao,et al."microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation".FISH & SHELLFISH IMMUNOLOGY 119(2021):420-431. |
入库方式： OAI收割
来源：海洋研究所
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