miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2
文献类型：期刊论文
| 作者 | Wu, Ning1; Xiao, Lin1; Zhao, Xiangzhong2; Zhao, Jin1; Wang, Jianpeng3; Wang, Fengxia1; Cao, Shousong4; Lin, XiuKun1,5 |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2012-11-02 |
| 卷号 | 586期号:21页码:3831-3839 |
| 关键词 | microRNA Glioblastoma stem cell Brain tumor microRNA-125b E2F2 |
| ISSN号 | 0014-5793 |
| 通讯作者 | Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China. |
| 英文摘要 | microRNAs (miRNAs) play important role in regulating cancer stem cell self-renewal and differentiation, but the expression prolife of miRNAs in glioma stem cells (GSCs) has not been addressed. Here, we found that CD133 positive GSCs possess a unique miRNAs profile compared to CD133 negative glioblastoma cells. miR-125b, as one of neuronal miRNAs, is the most significantly down-regulated miRNAs and overexpression of miR-125b inhibits the proliferation of CD133 positive GSCs and reduces the expression of "stem" marker. Furthermore, two binding sites for miR-125b are identified in the 3'UTR of E2F2 and overexpression of miR-125b in CD133 positive GSCs represses the endogenous level of E2F2 protein. This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 收录类别 | SCI |
| 原文出处 | 10.1016/j.febslet.2012.08.023 |
| 语种 | 英语 |
| WOS记录号 | WOS:000310529000011 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12361]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Shandong Acad Med Sci, Key Lab Modern Med & Technol Shandong Prov, Inst Basic Med, Jinan 250062, Peoples R China 3.Qingdao Med Univ, Affiliated Hosp, Inst Brain, Qingdao 266003, Peoples R China 4.Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA 5.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Ning,Xiao, Lin,Zhao, Xiangzhong,et al. miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2[J]. FEBS LETTERS,2012,586(21):3831-3839. |
| APA | Wu, Ning.,Xiao, Lin.,Zhao, Xiangzhong.,Zhao, Jin.,Wang, Jianpeng.,...&Lin, XiuKun.(2012).miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2.FEBS LETTERS,586(21),3831-3839. |
| MLA | Wu, Ning,et al."miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2".FEBS LETTERS 586.21(2012):3831-3839. |
入库方式： OAI收割
来源：海洋研究所
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