Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway
文献类型：期刊论文
| 作者 | He, Jian1,2; Wu, Zhiwen1; Chen, Liying1; Dai, Qi1; Hao, Huanhuan1; Su, Pei1; Ke, Caihuan1,3; Feng, Danqing1 |
| 刊名 | ACS CHEMICAL BIOLOGY
 |
| 出版日期 | 2021-08-20 |
| 卷号 | 16期号:8页码:1390-1400 |
| ISSN号 | 1554-8929 |
| DOI | 10.1021/acschembio.1c00175 |
| 通讯作者 | Feng, Danqing(dqfeng@xmu.edu.cn) |
| 英文摘要 | Settlement and metamorphosis of planktonic larvae into benthic adults are critical components of a diverse range of marine invertebrate-mediated processes such as the formation of mussel beds and coral reefs, the recruitment of marine shellfisheries, and the initiation of macrobiofouling. Although larval settlement and metamorphosis induced by natural chemical cues is widespread among marine invertebrates, the mechanisms of action remain poorly understood. Here, we identified that the molecular target of adenosine (an inducer of larval settlement and metamorphosis from conspecific adults in the invasive biofouling mussel Mytilopsis sallei) is adenosine kinase (ADK). The results of transcriptomic analyses, pharmacological assays, temporal and spatial gene expression analyses, and siRNA interference, suggest that ATP-dependent phosphorylation of adenosine catalyzed by ADK activates the downstream AMPK-FoxO signaling pathway, inducing larval settlement and metamorphosis in M. sallei. This study not only reveals the role of the ADK-AMPK-FoxO pathway in larval settlement and metamorphosis of marine invertebrates but it also deepens our understanding of the functions and evolution of adenosine signaling, a process that is widespread in biology and important in medicine. |
| 资助项目 | National Key Research and Development Program of China[2018YFC1407505] ; National Natural Science Foundation of China[41276127] ; Youth Innovation Fund Project of Xiamen[3502Z20206053] ; Project of Key Laboratory of Marine Ecological Monitoring and Restoration Technology, Ministry of Nature Resources[2020ZX01] ; Science and Technology Project of Fujian Province[2018Y0076] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000697396400011 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/176445]  |
| 专题 | 海洋研究所_海洋腐蚀与防护研究发展中心 |
| 通讯作者 | Feng, Danqing |
| 作者单位 | 1.Xiamen Univ, Coll Ocean & Earth Sci, State Prov Joint Engn Lab Marine Bioprod & Techno, Xiamen 361102, Peoples R China 2.Chinese Acad Sci, Key Lab Marine Environm Corros & Biofouling, Inst Oceanol, Qingdao 266071, Peoples R China 3.Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361102, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Jian,Wu, Zhiwen,Chen, Liying,et al. Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway[J]. ACS CHEMICAL BIOLOGY,2021,16(8):1390-1400. |
| APA | He, Jian.,Wu, Zhiwen.,Chen, Liying.,Dai, Qi.,Hao, Huanhuan.,...&Feng, Danqing.(2021).Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway.ACS CHEMICAL BIOLOGY,16(8),1390-1400. |
| MLA | He, Jian,et al."Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway".ACS CHEMICAL BIOLOGY 16.8(2021):1390-1400. |
入库方式： OAI收割
来源：海洋研究所
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