SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway
文献类型：期刊论文
| 作者 | Zhao, Ying2; Chen, Huan2; Shang, Zhuo1; Jiao, Binghua2; Yuan, Bin2; Sun, Weizhang3; Wang, Bingui1 ; Miao, Mingyong2; Huang, Caiguo2
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2012-06-01 |
| 卷号 | 10期号:6页码:1345-1359 |
| 关键词 | SD118-xanthocillin X (1) autophagy apoptosis ERK Beclin 1 |
| ISSN号 | 1660-3397 |
| 通讯作者 | Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China. |
| 英文摘要 | A compound named SD118-xanthocillin X (1) (C18H12N2O2), isolated from Penicillium commune in a deep-sea sediment sample, has been shown to inhibit the growth of several cancer cell lines in vitro. In the present study, we employed a growth inhibition assay and apoptotic analysis to identify the biological effect and detailed mechanism of SD118-xanthocillin X (1) in human hepatocellular carcinoma (HepG2) cells. SD118-xanthocillin X (1) demonstrated a concentration-dependent inhibitory effect on the growth of HepG2 cells and caused slight cellular apoptosis and significantly induced autophagy. Autophagy was detected as early as 12 h by the conversion of microtubule-associated protein 1 light chain 3 (LC3-I) to LC3-II, following cleavage and lipid addition to LC3-I. The pharmacological autophagy inhibitor 3-methyladenine largely attenuates the growth inhibition and autophagic effect of SD118-xanthocillin X (1) in HepG2 cells. Our data also indicated that the autophagic effect of SD118-xanthocillin X (1) occurs via the down-regulation of the MEK/ERK signaling pathway and the up-regulated class III PI3K/Beclin 1 signaling pathway. |
| 学科主题 | Chemistry, Medicinal |
| 收录类别 | SCI |
| 原文出处 | 10.3390/md10061345 |
| 语种 | 英语 |
| WOS记录号 | WOS:000305799800012 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12376]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China 3.Gen Hosp Chengdu Mil Command, PET Positron Emiss Computed Tomog Ctr, Chengdu 610083, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ying,Chen, Huan,Shang, Zhuo,et al. SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway[J]. MARINE DRUGS,2012,10(6):1345-1359. |
| APA | Zhao, Ying.,Chen, Huan.,Shang, Zhuo.,Jiao, Binghua.,Yuan, Bin.,...&Huang, Caiguo.(2012).SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway.MARINE DRUGS,10(6),1345-1359. |
| MLA | Zhao, Ying,et al."SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway".MARINE DRUGS 10.6(2012):1345-1359. |
入库方式： OAI收割
来源：海洋研究所
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