Neighboring Lithium-Assisted [1,2]-Wittig Rearrangement: Practical Access to Diarylmethanol-Based 1,4-Diols and Optically Active BINOL Derivatives with Axial and sp3-Central Chirality
文献类型：期刊论文
| 作者 | Gao G(高广) ; Gu FL(顾锋雷) ; Jiang JX(蒋剑雄) ; Jiang KZ(蒋可志) ; Sheng CJ(盛春荠) ; Lai GQ(来国桥) ; Xu LW(徐利文) |
| 刊名 | Chem. Eur. J.
 |
| 出版日期 | 2011 |
| 卷号 | 17页码:2698-2703 |
| 关键词 | asymmetric synthesis chirality chirality transfer diols Wittig rearrangement |
| ISSN号 | 0947-6539 |
| 通讯作者 | 徐利文 |
| 中文摘要 | A facile and practical methodology for the synthesis of synthetically useful diarylmethanol-based 1,4- diols and enantiomerically pure BINOL-derived diols with axial and sp3-central chirality has been developed through neighboring lithium-promoted [1,2]-Wittig rearrangement. The chirality transfer process shows a broad substrate scope in terms of the aromatic ether substituent, which allows access to a broad of range of chiral 1,1’-binaphthalene- 2-a-arylACHTUNGTRENUNGmethanol-2’-ols with excellent enantioselectivities (>99% enantiomeric excess) and yields (84–96%). This should be considered as an available and attractACHTUNGTRENUNGive chiral source to design and prepare privileged ligands or catalysts. |
| 学科主题 | 物理化学 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (NSFC, No. 20973051);Zhejiang Provincial Natural Science Foundation of China (Y4090139) |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://210.77.64.217/handle/362003/3780]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao G,Gu FL,Jiang JX,et al. Neighboring Lithium-Assisted [1,2]-Wittig Rearrangement: Practical Access to Diarylmethanol-Based 1,4-Diols and Optically Active BINOL Derivatives with Axial and sp3-Central Chirality[J]. Chem. Eur. J.,2011,17:2698-2703. |
| APA | Gao G.,Gu FL.,Jiang JX.,Jiang KZ.,Sheng CJ.,...&Xu LW.(2011).Neighboring Lithium-Assisted [1,2]-Wittig Rearrangement: Practical Access to Diarylmethanol-Based 1,4-Diols and Optically Active BINOL Derivatives with Axial and sp3-Central Chirality.Chem. Eur. J.,17,2698-2703. |
| MLA | Gao G,et al."Neighboring Lithium-Assisted [1,2]-Wittig Rearrangement: Practical Access to Diarylmethanol-Based 1,4-Diols and Optically Active BINOL Derivatives with Axial and sp3-Central Chirality".Chem. Eur. J. 17(2011):2698-2703. |
入库方式： OAI收割
来源：兰州化学物理研究所
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