Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats
文献类型：期刊论文
| 作者 | Wang, Z. F.; Wang, M. Y.; Yu, D. H.; Zhao, Y.; Xu, H. M.; Zhong, S.; Sun, W. Y.; He, Y. F.; Niu, J. Q.; Gao, P. J. |
| 刊名 | Molecular Medicine Reports
 |
| 出版日期 | 2018 |
| 卷号 | 18期号:3页码:3211-3218 |
| ISSN号 | 1791-2997 |
| 关键词 | hepatic fibrosis chitosan alpha-smooth muscle actin collagen 3 induced liver fibrosis acid phenethyl ester oxidative stress stellate cells drug-delivery derivatives activation mice injury Oncology Research & Experimental Medicine |
| DOI | 10.3892/mmr.2018.9343 |
| 英文摘要 | Chitosan is a linear polysaccharide that is made by treating the chitin shells of shrimp and crustaceans with an alkaline substance, for example sodium hydroxide. Due to its unique physical and chemical properties, chitosan has a wide range of applications in the medical field. Currently, there are no effective treatments for liver fibrosis; therefore, the aim of the present study was to investigate the therapeutic effect of chitosan in a CCl4-induced hepatic fibrosis (HF) rat model. The serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were measured by ELISA. Collagen (COL) 3 and alpha-smooth muscle actin (SMA) expression levels in the rat liver were detected by reverse transcription-semiquantitative polymerase chain reaction and western blotting, respectively. The results demonstrated that treatment with chitosan significantly improved HF, by decreasing the serum levels of AST, ALT, and ALP; improving liver histology; and decreasing the expression levels of COL3 and alpha-SMA. Chitosan may offer an alternative approach for the clinical treatment of HF. |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/60834]  |
| 专题 | 中国科学院长春光学精密机械与物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Z. F.,Wang, M. Y.,Yu, D. H.,et al. Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats[J]. Molecular Medicine Reports,2018,18(3):3211-3218. |
| APA | Wang, Z. F..,Wang, M. Y..,Yu, D. H..,Zhao, Y..,Xu, H. M..,...&Li, H. J..(2018).Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats.Molecular Medicine Reports,18(3),3211-3218. |
| MLA | Wang, Z. F.,et al."Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats".Molecular Medicine Reports 18.3(2018):3211-3218. |
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