Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy
文献类型：期刊论文
| 作者 | C.Zhang; Q.Q.Li; Y.Zhao; H.Liu; S.L.Song; Y.Q.Zhao; Q.Lin; Y.L.Chang |
| 刊名 | Journal of Materials Chemistry B
 |
| 出版日期 | 2019 |
| 卷号 | 7期号:4页码:548-555 |
| 关键词 | multidrug-resistance,shell nanoparticles,targeted delivery,p-glycoprotein,drug-delivery,doxorubicin,cancer,therapy,release,nanoplatform,Materials Science |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c8tb02939c |
| 英文摘要 | Synergistic thermo-chemotherapy based multiple stimuli-responsive drug delivery systems have achieved significant improvement of cancer curative effects compared with single modality treatment. Nevertheless, the efficacy of thermo-chemotherapy is often reduced in drug-resistant tumors and the therapy method is unexpectedly associated with potential toxicity by utilizing poorly degradable materials. Here, we report a simple approach to encapsulate three drug payloads into multi-sensitive and degradable nanospheres (SDC@NS) to achieve anticancer effects. SDC@NS comprise a photothermal agent (cypate), an anticancer agent (doxorubicin), and a nitric oxide donor (SNAP) to achieve controllable drugs release in high concentration glutathione or under near-infrared light (NIR) irradiation. Hyperthermia from NIR-mediated cypate can accelerate cancer cell apoptosis in vitro and tumor tissue ablation in vivo. Furthermore, our results also confirmed that the nitric oxide-based SDC@NS showed significant cytotoxicity compared to the nitric oxide absent group (denoted as DC@NS) and an enhanced chemotherapy effect in vivo. The photothermal effect and payloads can synchronously realize cancer therapy and provide a new insight into the enhanced synergistic therapeutic effect. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/62823]  |
| 专题 | 中国科学院长春光学精密机械与物理研究所 |
| 推荐引用方式 GB/T 7714 | C.Zhang,Q.Q.Li,Y.Zhao,et al. Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy[J]. Journal of Materials Chemistry B,2019,7(4):548-555. |
| APA | C.Zhang.,Q.Q.Li.,Y.Zhao.,H.Liu.,S.L.Song.,...&Y.L.Chang.(2019).Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy.Journal of Materials Chemistry B,7(4),548-555. |
| MLA | C.Zhang,et al."Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy".Journal of Materials Chemistry B 7.4(2019):548-555. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。