DNA-based digital comparator systems constructed by multifunctional nanoswitches
文献类型：期刊论文
| 作者 | H.M.Geng; C.Y.Zhou; C.L.Guo |
| 刊名 | Nanoscale
 |
| 出版日期 | 2019 |
| 卷号 | 11期号:45页码:21856-21866 |
| 关键词 | enzyme-free,strand displacement,logic operations,universal platform,nucleic-acids |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c9nr08216f |
| 英文摘要 | In this paper, we propose a strategy involving coupling DNA structural nanoswitches with toehold mediated strand displacement for constructing novel DNA-based digital comparator (DC) logic systems, which are a basic part of traditional electronic computers and can compare whether two or more input numbers are equal. However, when the number of DC inputs is increased to a certain level, the speed and quality of the computing circuit can be affected because of the limitations of conventional electronic computers when it comes to handling large-scale quantities of data. To solve this problem, in this work, we introduce a multi-input to multi-output DNA switch-based platform that can enable complex DC logical comparison. These multifunctional DNA-based switches, each including two hairpin-shaped molecular beacons and a G4/NMM complex, were used as platforms for the step-by-step realization of 2-3 DC, 3-3 DC, and 4-3 DC logic operations. Also, experiments were designed to further verify the excellent selectivity, achieving single-base mismatch operations with the digital comparator. Based on our design, comparators (">", "<" and "=") can be realized. Our prototype can inspire new designs and have intelligent digital comparator and in-field applications. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/63365]  |
| 专题 | 中国科学院长春光学精密机械与物理研究所 |
| 推荐引用方式 GB/T 7714 | H.M.Geng,C.Y.Zhou,C.L.Guo. DNA-based digital comparator systems constructed by multifunctional nanoswitches[J]. Nanoscale,2019,11(45):21856-21866. |
| APA | H.M.Geng,C.Y.Zhou,&C.L.Guo.(2019).DNA-based digital comparator systems constructed by multifunctional nanoswitches.Nanoscale,11(45),21856-21866. |
| MLA | H.M.Geng,et al."DNA-based digital comparator systems constructed by multifunctional nanoswitches".Nanoscale 11.45(2019):21856-21866. |
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