Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides
文献类型:期刊论文
作者 | Cao, Dong-Hua; Yao, Jian-Neng; Sun, Peng; Ji, Kai-Long; Li, Xiao-Nian; Cai, Qiang; Xiao, Chun-Fen; Hu, Hua-Bin; Yu, Zhi-Yong; Xu, You-Kai |
刊名 | FITOTERAPIA |
出版日期 | 2021 |
卷号 | 153期号:x页码:- |
ISSN号 | 0367-326X |
关键词 | Trichilia connaroides Meliaceae Limonoid Cytotoxicity Anti-inflammatory |
DOI | 10.1016/j.fitote.2021.105001 |
英文摘要 | Four new limonoids, named as trichiconlide G (1), 2-hydroxyltrijugin F (2), 23-oxo-21-hydroxyltrijugin F (3), 21-oxo-23-hydroxyltrijugin F (4), along with sixteen known analogues (5-20) were isolated from the leaves and twigs of Trichilia connaroides. Their structures and absolute configurations were determined by spectroscopic analyses, X-ray diffraction analysis, and TD-DFT-ECD calculations. Trichiconlide G (1) is one rare naturally occurring 1,2-seco phragmalin-type limonoid bearing a C-7/28 delta-lactone ring. Additionally, 2-hydroxyltrijugin F (2), 23-oxo-21-hydroxyltrijugin F (3), and 21-oxo-23-hydroxyltrijugin F (4) are three naturally occurring limonoids with a rare C-16/8 delta-lactone ring. All isolates were evaluated for their cytotoxic and anti-inflammatory activities. None of compounds exhibited cytotoxicity against five human cancer cell lines A-549, HepG2, 5-8F, Siha, and SCC-4 at the concentration of 40 mu M. Compounds 16 and 17 showed moderate anti-inflammatory activity with IC50 values of 28.45 +/- 2.51 and 22.66 +/- 2.01 mu M, respectively. |
学科主题 | Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000684837300008 |
源URL | [http://ir.xtbg.org.cn/handle/353005/12304] |
专题 | 西双版纳热带植物园_民族植物学研究组 |
作者单位 | 1.Second Peoples Hosp Yunnan Prov, Dept Hepatobiliary Surg, Kunming 650021, Peoples R China 2.[Cai, Qiang 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 4.[Yao, Jian-Neng 5.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China 6.Hu, Hua-Bin 7.Xiao, Chun-Fen 8.Ji, Kai-Long 9.Sun, Peng 10.[Cao, Dong-Hua |
推荐引用方式 GB/T 7714 | Cao, Dong-Hua,Yao, Jian-Neng,Sun, Peng,et al. Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides[J]. FITOTERAPIA,2021,153(x):-. |
APA | Cao, Dong-Hua.,Yao, Jian-Neng.,Sun, Peng.,Ji, Kai-Long.,Li, Xiao-Nian.,...&Xu, You-Kai.(2021).Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides.FITOTERAPIA,153(x),-. |
MLA | Cao, Dong-Hua,et al."Structurally diverse limonoids and bio-active evaluation from Trichilia connaroides".FITOTERAPIA 153.x(2021):-. |
入库方式: OAI收割
来源:西双版纳热带植物园
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