Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses
文献类型：期刊论文
| 作者 | Zhou, Hong; Ji, Jingkai; Chen, Xing; Bi, Yuhai8; Li, Juan; Wang, Qihui8; Hu, Tao; Song, Hao7; Zhao, Runchu6,8; Chen, Yanhua |
| 刊名 | CELL
 |
| 出版日期 | 2021 |
| 卷号 | 184期号:17页码:4380-+ |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2021.06.008 |
| 英文摘要 | Despite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary origins of this virus are elusive. We describe a meta-transcriptomic study of 411 bat samples collected from a small geographical region in Yunnan province, China, between May 2019 and November 2020. We identified 24 full-length coronavirus genomes, including four novel SARS-CoV-2-related and three SARS-CoV-related viruses. Rhinolophus pusillus virus RpYN06 was the closest relative of SARS-CoV-2 in most of the genome, although it possessed a more divergent spike gene. The other three SARS-CoV-2-related coronaviruses carried a genetically distinct spike gene that could weakly bind to the hACE2 receptor in vitro. Ecological modeling predicted the co-existence of up to 23 Rhinolophus bat species, with the largest contiguous hot-spots extending from South Laos and Vietnam to southern China. Our study highlights the remarkable diversity of bat coronaviruses at the local scale, including close relatives of both SARS-CoV-2 and SARS-CoV. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000686554600004 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/12308]  |
| 专题 | 西双版纳热带植物园_2012年后新成立研究组 |
| 作者单位 | 1.Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Tai An 271000, Shandong, Peoples R China 2.Holmes, Edward C.] Univ Sydney, Sch Med Sci, Sydney, NSW 2006, Australia 3.Holmes, Edward C.] Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia 4.Hughes, Alice C.] Chinese Acad Sci, Ctr Conservat Biol, Core Bot Gardens, Mengla 666303, Yunnan, Peoples R China 5.Anhui Univ, Inst Phys Sci & Informat, Hefei 230039, Peoples R China 6.Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth RNIH, Beijing 100101, Peoples R China 7.Chinese Acad Sci, CAS Ctr Influenza Res & Early Warning CASCIRE, CAS TWAS Ctr Excellence Emerging Infect Dis CEEID, Inst Microbiol,CAS Key Lab Pathogen Microbiol & I, Beijing 100101, Peoples R China 8.Chen, Xing; Chen, Yanhua; Hughes, Alice C.] Chinese Acad Sci, Ctr Integrat Conservat, Landscape Ecol Grp, Xishuangbanna Trop Bot Garden, Mengla 666303, Yunnan, Peoples R China 9.Shandong First Med Univ & Shandong Acad Med Sci, Key Lab Etiol & Epidemiol Emerging Infect Dis Uni, Tai An 271000, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Hong,Ji, Jingkai,Chen, Xing,et al. Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses[J]. CELL,2021,184(17):4380-+. |
| APA | Zhou, Hong.,Ji, Jingkai.,Chen, Xing.,Bi, Yuhai.,Li, Juan.,...&Shi, Weifeng.(2021).Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses.CELL,184(17),4380-+. |
| MLA | Zhou, Hong,et al."Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses".CELL 184.17(2021):4380-+. |
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来源：西双版纳热带植物园
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