New bioactive peptides from the venom gland of a social hornet Vespa velutina
文献类型：期刊论文
| 作者 | Meng, Yi-Chuan; Mo, Xiang-Gui; He, Tian-Tian; Wen, Xin-Xin; Nieh, James-C; Yang, Xin-Wang; Tan, Ken6
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| 刊名 | TOXICON
 |
| 出版日期 | 2021 |
| 卷号 | 199期号:x页码:94-100 |
| 关键词 | Vespa velutina Venom gland Antimicrobial peptides Antioxidative peptides |
| ISSN号 | 0041-0101 |
| DOI | 10.1016/j.toxicon.2021.06.002 |
| 英文摘要 | Bacterial resistance to drugs is a global problem requiring the urgent development of new antibiotics. Antimicrobial peptides (AMPs) are excellent candidates for the design of novel antibiotics to combat microbial resistance. In this research, we identified four new peptides (U-VVTX-Vp1a, U-VVTX-Vp1b, U-VVTX-Vp2a, and UVVTX-Vp2b, respectively) from the venom of Vespa velutina, and tested their antimicrobial, antioxidant, and hemolytic effects. All four peptides showed scavenging ability against DPPH, ABTS+, and center dot OH free radicals. Of note, Vp1b strongly inhibited the growth of Staphylococcus aureus and Escherichia coli bacteria at concentrations of 60 and 120 mu M. Due to their low hemolytic activity, all four peptides could be utilized in the development of new antioxidants and as candidates for the design of novel antimicrobial agents. |
| 学科主题 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000675540600004 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/12321]  |
| 专题 | 西双版纳热带植物园_2012年后新成立研究组 |
| 作者单位 | 1.Univ Calif San Diego, Div Biol Sci, Sect Ecol Behav & Evolut, La Jolla, CA 92093 USA 2.Kunming Med Univ, Fac Basic Med Sci, Dept Anat & Histol & Embryol, Kunming 650500, Yunnan, Peoples R China 3.[He, Tian-Tian 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, CAS Key Lab Trop Forest Ecol, Xishuangbanna Trop Bot Garden, Kunming 650000, Yunnan, Peoples R China 6.Wen, Xin-Xin 7.Mo, Xiang-Gui 8.[Meng, Yi-Chuan |
| 推荐引用方式 GB/T 7714 | Meng, Yi-Chuan,Mo, Xiang-Gui,He, Tian-Tian,et al. New bioactive peptides from the venom gland of a social hornet Vespa velutina[J]. TOXICON,2021,199(x):94-100. |
| APA | Meng, Yi-Chuan.,Mo, Xiang-Gui.,He, Tian-Tian.,Wen, Xin-Xin.,Nieh, James-C.,...&Tan, Ken.(2021).New bioactive peptides from the venom gland of a social hornet Vespa velutina.TOXICON,199(x),94-100. |
| MLA | Meng, Yi-Chuan,et al."New bioactive peptides from the venom gland of a social hornet Vespa velutina".TOXICON 199.x(2021):94-100. |
入库方式： OAI收割
来源：西双版纳热带植物园
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