Predicting Brain Regions Related to Alzheimer's Disease Based on Global Feature
文献类型：期刊论文
| 作者 | Wang, Qi4,5; Chen, Siwei3; Wang, He2; Chen, Luzeng1; Sun, Yongan3; Yan, Guiying4,5
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| 刊名 | FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
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| 出版日期 | 2021-05-21 |
| 卷号 | 15页码:9 |
| 关键词 | Alzheimer's disease diffusion tensor imaging brain structural network 2hop-connectivity global featurescore differential network analysis |
| DOI | 10.3389/fncom.2021.659838 |
| 英文摘要 | Alzheimer's disease (AD) is a neurodegenerative disease that commonly affects the elderly; early diagnosis and timely treatment are very important to delay the course of the disease. In the past, most brain regions related to AD were identified based on imaging methods, and only some atrophic brain regions could be identified. In this work, the authors used mathematical models to identify the potential brain regions related to AD. In this study, 20 patients with AD and 13 healthy controls (non-AD) were recruited by the neurology outpatient department or the neurology ward of Peking University First Hospital from September 2017 to March 2019. First, diffusion tensor imaging (DTI) was used to construct the brain structural network. Next, the authors set a new local feature index 2hop-connectivity to measure the correlation between different regions. Compared with the traditional graph theory index, 2hop-connectivity exploits the higher-order information of the graph structure. And for this purpose, the authors proposed a novel algorithm called 2hopRWR to measure 2hop-connectivity. Then, a new index global feature score (GFS) based on a global feature was proposed by combing five local features, namely degree centrality, betweenness centrality, closeness centrality, the number of maximal cliques, and 2hop-connectivity, to judge which brain regions are related to AD. As a result, the top ten brain regions identified using the GFS scoring difference between the AD and the non-AD groups were associated to AD by literature verification. The results of the literature validation comparing GFS with the local features showed that GFS was superior to individual local features. Finally, the results of the canonical correlation analysis showed that the GFS was significantly correlated with the scores of the Mini-Mental State Examination (MMSE) scale and the Montreal Cognitive Assessment (MoCA) scale. Therefore, the authors believe the GFS can also be used as a new biomarker to assist in diagnosis and objective monitoring of disease progression. Besides, the method proposed in this paper can be used as a differential network analysis method for network analysis in other domains. |
| 资助项目 | National Natural Science Foundation of China[11631014] |
| WOS研究方向 | Mathematical & Computational Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000657649500001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/58746]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Sun, Yongan; Yan, Guiying |
| 作者单位 | 1.Peking Univ First Hosp, Dept Ultrasound, Beijing, Peoples R China 2.Peking Univ First Hosp, Dept Med Imaging, Beijing, Peoples R China 3.Peking Univ First Hosp, Dept Neurol, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qi,Chen, Siwei,Wang, He,et al. Predicting Brain Regions Related to Alzheimer's Disease Based on Global Feature[J]. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,2021,15:9. |
| APA | Wang, Qi,Chen, Siwei,Wang, He,Chen, Luzeng,Sun, Yongan,&Yan, Guiying.(2021).Predicting Brain Regions Related to Alzheimer's Disease Based on Global Feature.FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,15,9. |
| MLA | Wang, Qi,et al."Predicting Brain Regions Related to Alzheimer's Disease Based on Global Feature".FRONTIERS IN COMPUTATIONAL NEUROSCIENCE 15(2021):9. |
入库方式： OAI收割
来源：数学与系统科学研究院
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