The Asymptotic Behavior of Bootstrap Support Values in Molecular Phylogenetics
文献类型：期刊论文
| 作者 | Huang, Jun2,3; Liu, Yuting3; Zhu, Tianqi1 ; Yang, Ziheng2
|
| 刊名 | SYSTEMATIC BIOLOGY
 |
| 出版日期 | 2021-07-01 |
| 卷号 | 70期号:4页码:774-785 |
| 关键词 | Bootstrap model selection star-tree paradox support value |
| ISSN号 | 1063-5157 |
| DOI | 10.1093/sysbio/syaa100 |
| 英文摘要 | The phylogenetic bootstrap is the most commonly used method for assessing statistical confidence in estimated phylogenies by non-Bayesian methods such as maximum parsimony and maximum likelihood (ML). It is observed that bootstrap support tends to be high in large genomic data sets whether or not the inferred trees and clades are correct. Here, we study the asymptotic behavior of bootstrap support for the ML tree in large data sets when the competing phylogenetic trees are equally right or equally wrong. We consider phylogenetic reconstruction as a problem of statistical model selection when the compared models are nonnested and misspecified. The bootstrap is found to have qualitatively different dynamics from Bayesian inference and does not exhibit the polarized behavior of posterior model probabilities, consistent with the empirical observation that the bootstrap is more conservative than Bayesian probabilities. Nevertheless, bootstrap support similarly shows fluctuations among large data sets, with no convergence to a point value, when the compared models are equally right or equally wrong. Thus, in large data sets strong support for wrong trees or models is likely to occur. Our analysis provides a partial explanation for the high bootstrap support values for incorrect clades observed in empirical data analysis. |
| WOS研究方向 | Evolutionary Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000671573900010 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/58917]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Liu, Yuting; Zhu, Tianqi; Yang, Ziheng |
| 作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Key Lab Random Complex Struct,Data Sci, Beijing 100000, Peoples R China 2.UCL, Dept Genet Evolut & Environm, Gower St, London WC1E 6BT, England 3.Beijing Jiaotong Univ, Dept Math, Beijing 100044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Jun,Liu, Yuting,Zhu, Tianqi,et al. The Asymptotic Behavior of Bootstrap Support Values in Molecular Phylogenetics[J]. SYSTEMATIC BIOLOGY,2021,70(4):774-785. |
| APA | Huang, Jun,Liu, Yuting,Zhu, Tianqi,&Yang, Ziheng.(2021).The Asymptotic Behavior of Bootstrap Support Values in Molecular Phylogenetics.SYSTEMATIC BIOLOGY,70(4),774-785. |
| MLA | Huang, Jun,et al."The Asymptotic Behavior of Bootstrap Support Values in Molecular Phylogenetics".SYSTEMATIC BIOLOGY 70.4(2021):774-785. |
入库方式： OAI收割
来源：数学与系统科学研究院
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