中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 数学与系统科学研究院
  3. 中国科学院数学与系统科学研究院
  4. 应用数学研究所
Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF

文献类型：期刊论文

作者Zhou, Guofeng5; Sun, Shaoyan4; Yuan, Qiuyue2,3; Zhang, Run4; Jiang, Ping5; Li, Guangyu3; Wang, Yong2,3; Li, Xiao1
刊名FRONTIERS IN GENETICS
出版日期2021-07-08
卷号12页码:14
关键词heart failure with preserved ejection fraction differentially expressed genes differentially correlated gene pairs differential network molecular docking
DOI10.3389/fgene.2021.668702
英文摘要Heart failure with preserved ejection fraction (HFpEF) is a complex disease characterized by dysfunctions in the heart, adipose tissue, and cerebral arteries. The elucidation of the interactions between these three tissues in HFpEF will improve our understanding of the mechanism of HFpEF. In this study, we propose a multilevel comparative framework based on differentially expressed genes (DEGs) and differentially correlated gene pairs (DCGs) to investigate the shared and unique pathological features among the three tissues in HFpEF. At the network level, functional enrichment analysis revealed that the networks of the heart, adipose tissue, and cerebral arteries were enriched in the cell cycle and immune response. The networks of the heart and adipose tissues were enriched in hemostasis, G-protein coupled receptor (GPCR) ligand, and cancer-related pathway. The heart-specific networks were enriched in the inflammatory response and cardiac hypertrophy, while the adipose-tissue-specific networks were enriched in the response to peptides and regulation of cell adhesion. The cerebral-artery-specific networks were enriched in gene expression (transcription). At the module and gene levels, 5 housekeeping DEGs, 2 housekeeping DCGs, 6 modules of merged protein-protein interaction network, 5 tissue-specific hub genes, and 20 shared hub genes were identified through comparative analysis of tissue pairs. Furthermore, the therapeutic drugs for HFpEF-targeting these genes were examined using molecular docking. The combination of multitissue and multilevel comparative frameworks is a potential strategy for the discovery of effective therapy and personalized medicine for HFpEF.
资助项目Chinese National Natural Science Foundations[81673970] ; Chinese National Natural Science Foundations[11901272] ; National Key Research and Development Program of China[2020YFA0712402]
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:000675498900001
出版者FRONTIERS MEDIA SA
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/58950]  
专题应用数学研究所
通讯作者Sun, Shaoyan; Li, Xiao
作者单位1.Shandong Univ Tradit Chinese Med, Dept Cardiovasc, Affiliated Hosp, Jinan, Peoples R China
2.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, CEMS, NCMIS, Beijing, Peoples R China
4.Ludong Univ, Sch Math & Stat, Yantai, Peoples R China
5.Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Guofeng,Sun, Shaoyan,Yuan, Qiuyue,et al. Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF[J]. FRONTIERS IN GENETICS,2021,12:14.
APA Zhou, Guofeng.,Sun, Shaoyan.,Yuan, Qiuyue.,Zhang, Run.,Jiang, Ping.,...&Li, Xiao.(2021).Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF.FRONTIERS IN GENETICS,12,14.
MLA Zhou, Guofeng,et al."Multiple-Tissue and Multilevel Analysis on Differentially Expressed Genes and Differentially Correlated Gene Pairs for HFpEF".FRONTIERS IN GENETICS 12(2021):14.

入库方式： OAI收割

来源：数学与系统科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。